biostudies-literatureUnknown9(4)Cummings MA<h4>Background</h4>Squamous cell carcinoma of unknown primary of the head and neck region is a known entity described mainly by retrospective reports. We searched a hospital-based registry to better describe the changing incidence, and to assess diagnostic and treatment strategies.<h4>Methods</h4>The National Comprehensive Cancer Database was queried for head and neck cancers from oropharynx, tonsil, tongue, larynx, hypopharynx primary sites with a designation of clinical T0, representing an unknown primary. Kaplan Meier, Cox multivariate models, and propensity matched cohorts were used to assess significant factors for overall survival.<h4>Results</h4>There were 964 cases that met the criteria, and 468 cases with known treatments, staging, and survival data. The incidence increased over tAnnals of translational medicine284https://www.ebi.ac.uk/biostudies/studies/S-EPMC7944267biostudies-literatureSquamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry.PMC7944267Singh AKCummings MASingh DPVan Der Sloot PMa SJMilano MTfalseSquamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry.<h4>Background</h4>Squamous cell carcinoma of unknown primary of the head and neck region is a known entity described mainly by retrospective reports. We searched a hospital-based registry to better describe the changing incidence, and to assess diagnostic and treatment strategies.<h4>Methods</h4>The National Comprehensive Cancer Database was queried for head and neck cancers from oropharynx, tonsil, tongue, larynx, hypopharynx primary sites with a designation of clinical T0, representing an unknown primary. Kaplan Meier, Cox multivariate models, and propensity matched cohorts were used to assess significant factors for overall survival.<h4>Results</h4>There were 964 cases that met the criteria, and 468 cases with known treatments, staging, and survival data. The incidence increased over t2021-01-01T00:00:00Z2021 Feb2025-04-04T19:24:21.711Z2025-02-19T01:40:03.545ZS-EPMC79442673370891110.21037/atm-20-4631