{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(4)"],"submitter":["Yuan L"],"pubmed_abstract":["<h4>Background</h4>B7-H6 is a novel co-stimulatory protein exclusively expressed on a variety of cancer cells and associated with poor prognosis. T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive hematological malignancy whose treatment requires reliable prognostic biomarkers and therapeutic targets. However, the rare nature and delayed progression of T-LBL have limited its clinical management.<h4>Methods</h4>The expression of B7-H6 was analyzed by immunohistochemistry (IHC) in 65 T-LBL samples; the association with the clinicopathological characteristics and prognosis was also investigated. B7-H6-depleted Jurkat cells were also generated to investigate the effect of B7-H6 on cell proliferation, migration, and invasion. RNA sequencing was used to explore differentially expressed"],"journal":["Annals of translational medicine"],"pagination":["328"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7944329"],"repository":["biostudies-literature"],"pubmed_title":["B7-H6 is a new potential biomarker and therapeutic target of T-lymphoblastic lymphoma."],"pmcid":["PMC7944329"],"pubmed_authors":["Sun L","Jing H","Ke X","Yuan L","Chen X","Yang S","Wang J","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"B7-H6 is a new potential biomarker and therapeutic target of T-lymphoblastic lymphoma.","description":"<h4>Background</h4>B7-H6 is a novel co-stimulatory protein exclusively expressed on a variety of cancer cells and associated with poor prognosis. T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive hematological malignancy whose treatment requires reliable prognostic biomarkers and therapeutic targets. However, the rare nature and delayed progression of T-LBL have limited its clinical management.<h4>Methods</h4>The expression of B7-H6 was analyzed by immunohistochemistry (IHC) in 65 T-LBL samples; the association with the clinicopathological characteristics and prognosis was also investigated. B7-H6-depleted Jurkat cells were also generated to investigate the effect of B7-H6 on cell proliferation, migration, and invasion. RNA sequencing was used to explore differentially expressed","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-04T19:24:15.044Z","creation":"2025-02-19T01:40:07.826Z"},"accession":"S-EPMC7944329","cross_references":{"pubmed":["33708955"],"doi":["10.21037/atm-20-5308"]}}