biostudies-literatureUnknown9(4)Yuan L<h4>Background</h4>B7-H6 is a novel co-stimulatory protein exclusively expressed on a variety of cancer cells and associated with poor prognosis. T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive hematological malignancy whose treatment requires reliable prognostic biomarkers and therapeutic targets. However, the rare nature and delayed progression of T-LBL have limited its clinical management.<h4>Methods</h4>The expression of B7-H6 was analyzed by immunohistochemistry (IHC) in 65 T-LBL samples; the association with the clinicopathological characteristics and prognosis was also investigated. B7-H6-depleted Jurkat cells were also generated to investigate the effect of B7-H6 on cell proliferation, migration, and invasion. RNA sequencing was used to explore differentially expressedAnnals of translational medicine328https://www.ebi.ac.uk/biostudies/studies/S-EPMC7944329biostudies-literatureB7-H6 is a new potential biomarker and therapeutic target of T-lymphoblastic lymphoma.PMC7944329Sun LJing HKe XYuan LChen XYang SWang JZhao YfalseB7-H6 is a new potential biomarker and therapeutic target of T-lymphoblastic lymphoma.<h4>Background</h4>B7-H6 is a novel co-stimulatory protein exclusively expressed on a variety of cancer cells and associated with poor prognosis. T-cell lymphoblastic lymphoma (T-LBL) is a highly aggressive hematological malignancy whose treatment requires reliable prognostic biomarkers and therapeutic targets. However, the rare nature and delayed progression of T-LBL have limited its clinical management.<h4>Methods</h4>The expression of B7-H6 was analyzed by immunohistochemistry (IHC) in 65 T-LBL samples; the association with the clinicopathological characteristics and prognosis was also investigated. B7-H6-depleted Jurkat cells were also generated to investigate the effect of B7-H6 on cell proliferation, migration, and invasion. RNA sequencing was used to explore differentially expressed2021-01-01T00:00:00Z2021 Feb2025-04-04T19:24:15.044Z2025-02-19T01:40:07.826ZS-EPMC79443293370895510.21037/atm-20-5308