{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(3)"],"submitter":["Chenouard R"],"pubmed_abstract":["<h4>Background</h4>Gut colonization by ESBL-producing Enterobacteriaceae (ESBL-PE) is widespread and is promoted by antibiotic exposure. Higher fecal abundance of ESBL-PE promotes the dissemination of the bacteria in the environment and is associated with increased risk of infection. Ceftriaxone and temocillin are commonly used antibiotics with a different activity on gut flora. Their impact on fecal abundance of ESBL-producing Enterobacteriaceae has not been studied. The objective of this study was to compare the propensity of ceftriaxone and temocillin to modify the abundance of ESBL-producing Escherichia coli in feces of colonized mice.<h4>Methods</h4>Mice received broad-spectrum antibiotics in order to disrupt their normal gut flora. A CTX-M-type ESBL-producing E. coli clinical isolate"],"journal":["PloS one"],"pagination":["e0248177"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7946171"],"repository":["biostudies-literature"],"pubmed_title":["Impact of ceftriaxone and temocillin on fecal abundance of extended-spectrum β-lactamase producing Escherichia coli in a mouse model."],"pmcid":["PMC7946171"],"pubmed_authors":["Mahieu R","Marion E","Dubee V","Chenouard R","Eveillard M","Luque Paz D"],"additional_accession":[]},"is_claimable":false,"name":"Impact of ceftriaxone and temocillin on fecal abundance of extended-spectrum β-lactamase producing Escherichia coli in a mouse model.","description":"<h4>Background</h4>Gut colonization by ESBL-producing Enterobacteriaceae (ESBL-PE) is widespread and is promoted by antibiotic exposure. Higher fecal abundance of ESBL-PE promotes the dissemination of the bacteria in the environment and is associated with increased risk of infection. Ceftriaxone and temocillin are commonly used antibiotics with a different activity on gut flora. Their impact on fecal abundance of ESBL-producing Enterobacteriaceae has not been studied. The objective of this study was to compare the propensity of ceftriaxone and temocillin to modify the abundance of ESBL-producing Escherichia coli in feces of colonized mice.<h4>Methods</h4>Mice received broad-spectrum antibiotics in order to disrupt their normal gut flora. A CTX-M-type ESBL-producing E. coli clinical isolate","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-26T00:43:45.383Z","creation":"2025-04-06T09:47:24.533Z"},"accession":"S-EPMC7946171","cross_references":{"pubmed":["33690674"],"doi":["10.1371/journal.pone.0248177"]}}