{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tottenham N"],"funding":["NIMH NIH HHS","National Institute of Mental Health","John Templeton Foundation"],"pagination":["343-351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7946704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(3)"],"pubmed_abstract":["Background
Major depressive disorder (MDD) is associated with aberrant limbic neural responses to emotional stimuli. We assessed how self-generated emotions modulate trial-by-trial limbic activity and whether this brain-emotion synchrony varies by familial MDD risk (regardless of personal MDD history) and neuroticism.Methods
Participants (n = 74, mean age = 34 years) were later-generation family members of depressed or nondepressed probands as part of a longitudinal cohort study. Using an emotion induction task, we examined participant-specific modulation of anatomically defined limbic neurobiology. Neuroticism, mental health, and familial parenting style were assessed, and MDD assessments were routinely collected throughout the previous longitudinal assessments of the stud"],"journal":["Biological psychiatry. Cognitive neuroscience and neuroimaging"],"pubmed_title":["Depression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion."],"pmcid":["PMC7946704"],"funding_grant_id":["R01 MH036197","R01 MH091864","P50 MH090966"],"pubmed_authors":["Weissman MM","Tottenham N","Warner V","Gingrich JA","Peterson BS","Gameroff MJ","Hao X","Wang Z","Posner J","Semanek DP","Talati A"],"additional_accession":[]},"is_claimable":false,"name":"Depression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion.","description":"Background
Major depressive disorder (MDD) is associated with aberrant limbic neural responses to emotional stimuli. We assessed how self-generated emotions modulate trial-by-trial limbic activity and whether this brain-emotion synchrony varies by familial MDD risk (regardless of personal MDD history) and neuroticism.Methods
Participants (n = 74, mean age = 34 years) were later-generation family members of depressed or nondepressed probands as part of a longitudinal cohort study. Using an emotion induction task, we examined participant-specific modulation of anatomically defined limbic neurobiology. Neuroticism, mental health, and familial parenting style were assessed, and MDD assessments were routinely collected throughout the previous longitudinal assessments of the stud","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-18T15:11:02.732Z","creation":"2025-04-07T01:40:52.104Z"},"accession":"S-EPMC7946704","cross_references":{"pubmed":["33487578"],"doi":["10.1016/j.bpsc.2020.10.011"]}}