biostudies-literatureTottenham NNIMH NIH HHSNational Institute of Mental HealthJohn Templeton Foundation343-351https://www.ebi.ac.uk/biostudies/studies/S-EPMC7946704biostudies-literatureUnknown6(3)<h4>Background</h4>Major depressive disorder (MDD) is associated with aberrant limbic neural responses to emotional stimuli. We assessed how self-generated emotions modulate trial-by-trial limbic activity and whether this brain-emotion synchrony varies by familial MDD risk (regardless of personal MDD history) and neuroticism.<h4>Methods</h4>Participants (n = 74, mean age = 34 years) were later-generation family members of depressed or nondepressed probands as part of a longitudinal cohort study. Using an emotion induction task, we examined participant-specific modulation of anatomically defined limbic neurobiology. Neuroticism, mental health, and familial parenting style were assessed, and MDD assessments were routinely collected throughout the previous longitudinal assessments of the studBiological psychiatry. Cognitive neuroscience and neuroimagingDepression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion.PMC7946704R01 MH036197R01 MH091864P50 MH090966Weissman MMTottenham NWarner VGingrich JAPeterson BSGameroff MJHao XWang ZPosner JSemanek DPTalati AfalseDepression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion.<h4>Background</h4>Major depressive disorder (MDD) is associated with aberrant limbic neural responses to emotional stimuli. We assessed how self-generated emotions modulate trial-by-trial limbic activity and whether this brain-emotion synchrony varies by familial MDD risk (regardless of personal MDD history) and neuroticism.<h4>Methods</h4>Participants (n = 74, mean age = 34 years) were later-generation family members of depressed or nondepressed probands as part of a longitudinal cohort study. Using an emotion induction task, we examined participant-specific modulation of anatomically defined limbic neurobiology. Neuroticism, mental health, and familial parenting style were assessed, and MDD assessments were routinely collected throughout the previous longitudinal assessments of the stud2021-01-01T00:00:00Z2021 Mar2025-04-18T15:11:02.732Z2025-04-07T01:40:52.104ZS-EPMC79467043348757810.1016/j.bpsc.2020.10.011