biostudies-literatureUnknown12Xu YOne new (1) and fifteen known (2-16) p-terphenyls were isolated from a solid culture of the endophytic fungus Aspergillus sp. GZWMJZ-055 by adding the leaves of its host Eucommia ulmoides. Furthermore, nine p-terphenyls (17-25) were synthesized from the main compounds (5-7), among which derivatives 18, 19, 21, 22, and 25 are new p-terphenyls. Compounds 15 and 16 were also, respectively, synthesized from compounds 6 and 7 by oxidative cyclization of air in the presence of silica gel. These p-terphenyls especially those with 4,2',4″-trihydroxy (4-7, 20, 21) or 4, 4″-dihydroxy-1,2,1',2'-furan (15, 16) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.Frontiers in microbiology654963https://www.ebi.ac.uk/biostudies/studies/S-EPMC7947296biostudies-literaturep-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities.PMC7947296He WWu DZhu WWang YXu YWang Lfalsep-Terphenyls From Aspergillus sp. GZWMJZ-055: Identification, Derivation, Antioxidant and α-Glycosidase Inhibitory Activities.One new (1) and fifteen known (2-16) p-terphenyls were isolated from a solid culture of the endophytic fungus Aspergillus sp. GZWMJZ-055 by adding the leaves of its host Eucommia ulmoides. Furthermore, nine p-terphenyls (17-25) were synthesized from the main compounds (5-7), among which derivatives 18, 19, 21, 22, and 25 are new p-terphenyls. Compounds 15 and 16 were also, respectively, synthesized from compounds 6 and 7 by oxidative cyclization of air in the presence of silica gel. These p-terphenyls especially those with 4,2',4″-trihydroxy (4-7, 20, 21) or 4, 4″-dihydroxy-1,2,1',2'-furan (15, 16) substituted nucleus, exhibited significant antioxidant and α-glucosidase inhibitory activities and lower cytotoxicity to caco-2 cells. The results indicated their potential use as lead compounds or dietary supplements for treating or preventing the diabetes.2021-01-01T00:00:00Z20212024-12-04T07:39:25.084Z2021-03-14T08:21:06ZS-EPMC79472963371704810.3389/fmicb.2021.654963