biostudies-literatureUnknown10(2)Moldovanu DRandomized-controlled trials have confirmed substantial reductions in lung cancer mortality with low-dose computed tomography (LDCT) screening. Evidence on how to integrate smoking cessation support in lung cancer screening is however scarce. This represents a significant gap in the literature, as a combined strategy of lung cancer screening and smoking cessation greatly reduces the mortality risk due to lung cancer and other related comorbidities. In this review, a literature search in MEDLINE, Embase, Web of Science, the Cochrane Central Register of Controlled Trials and Google Scholar was performed to identify randomized-controlled and observational studies investigating the effect of lung cancer screening trials and integrated cessation interventions on smoking cessation. Of the 236 idTranslational lung cancer research1099-1109https://www.ebi.ac.uk/biostudies/studies/S-EPMC7947402biostudies-literatureLung cancer screening and smoking cessation efforts.PMC7947402van der Aalst CMde Koning HJMoldovanu DfalseLung cancer screening and smoking cessation efforts.Randomized-controlled trials have confirmed substantial reductions in lung cancer mortality with low-dose computed tomography (LDCT) screening. Evidence on how to integrate smoking cessation support in lung cancer screening is however scarce. This represents a significant gap in the literature, as a combined strategy of lung cancer screening and smoking cessation greatly reduces the mortality risk due to lung cancer and other related comorbidities. In this review, a literature search in MEDLINE, Embase, Web of Science, the Cochrane Central Register of Controlled Trials and Google Scholar was performed to identify randomized-controlled and observational studies investigating the effect of lung cancer screening trials and integrated cessation interventions on smoking cessation. Of the 236 id2021-01-01T00:00:00Z2021 Feb2025-04-26T18:34:49.649Z2025-02-19T01:41:02.189ZS-EPMC79474023371804810.21037/tlcr-20-899