biostudies-literatureUnknown10(2)Ferro M<h4>Background</h4>An accurate and early diagnosis of bladder cancer (BC) is essential to offer patients the most appropriate treatment and the highest cure rate. For this reason, patients need to be best stratified by class and risk factors. We aimed to develop a score able to better predict cancer outcomes, using serum variables of inflammation.<h4>Methods</h4>A total of 1,510 high-risk non-muscle invasive bladder cancer (NMIBC) patients were included in this retrospective observational study. Patients with pathologically proven T1 HG/G3 at first TURBT were included. Systemic combined inflammatory score (SCIS) was calculated according to systemic inflammatory markers (SIM), modified Glasgow prognostic score (mGPS), and prognostic nutritional index (PNI) dichotomized (final score from 0 tTranslational andrology and urology626-635https://www.ebi.ac.uk/biostudies/studies/S-EPMC7947442biostudies-literatureSystemic combining inflammatory score (SCIS): a new score for prediction of oncologic outcomes in patients with high-risk non-muscle-invasive urothelial bladder cancer.PMC7947442Marchioni MMorgia GDamiano RBusetto GMCimino SAbu Farhan ARMusi GFerro MDi Mauro MLucarelli GCordima GPerdona SSchips LBorghesi MVeccia AMirone VRusso GIMinervini ATerracciano DHurle RCrisan NSoria Fde Cobelli OPorreca AAutorino RVartolomei MDBattaglia MDel Giudice FMuto MMari ACantiello FBove PfalseSystemic combining inflammatory score (SCIS): a new score for prediction of oncologic outcomes in patients with high-risk non-muscle-invasive urothelial bladder cancer.<h4>Background</h4>An accurate and early diagnosis of bladder cancer (BC) is essential to offer patients the most appropriate treatment and the highest cure rate. For this reason, patients need to be best stratified by class and risk factors. We aimed to develop a score able to better predict cancer outcomes, using serum variables of inflammation.<h4>Methods</h4>A total of 1,510 high-risk non-muscle invasive bladder cancer (NMIBC) patients were included in this retrospective observational study. Patients with pathologically proven T1 HG/G3 at first TURBT were included. Systemic combined inflammatory score (SCIS) was calculated according to systemic inflammatory markers (SIM), modified Glasgow prognostic score (mGPS), and prognostic nutritional index (PNI) dichotomized (final score from 0 t2021-01-01T00:00:00Z2021 Feb2025-04-26T18:23:28.251Z2025-02-19T01:40:22.907ZS-EPMC79474423371806510.21037/tau-20-1272