biostudies-literatureUnknown13(2)Shao Y<h4>Background</h4>The effect of perioperative chemotherapy on patients with lymph node-negative esophageal cancer (EC) is controversial. This study explored which EC patients, staged under the T1-3N0M0, would benefit from perioperative chemotherapy.<h4>Methods</h4>Data on patients with diagnosed primary EC were retrieved from Surveillance, Epidemiology and End Results (SEER) database. Propensity score-matched (PSM) method was performed to balance baseline covariates. Multivariate Cox regression analysis and Kaplan-Meier curve were used to assess potential survival difference between patients undergoing surgery plus perioperative chemotherapy (SA + CT) and those undergoing surgery alone (SA).<h4>Results</h4>In a total of 2,711 EC patients (T1-3N0M0), 166 patients underwent SA + CT and 2,54Journal of thoracic disease995-1004https://www.ebi.ac.uk/biostudies/studies/S-EPMC7947537biostudies-literatureSurvival benefit of perioperative chemotherapy for T1-3N0M0 stage esophageal cancer: a SEER database analysis.PMC7947537Ye LWang XMShao YWu QCZhang CChen DfalseSurvival benefit of perioperative chemotherapy for T1-3N0M0 stage esophageal cancer: a SEER database analysis.<h4>Background</h4>The effect of perioperative chemotherapy on patients with lymph node-negative esophageal cancer (EC) is controversial. This study explored which EC patients, staged under the T1-3N0M0, would benefit from perioperative chemotherapy.<h4>Methods</h4>Data on patients with diagnosed primary EC were retrieved from Surveillance, Epidemiology and End Results (SEER) database. Propensity score-matched (PSM) method was performed to balance baseline covariates. Multivariate Cox regression analysis and Kaplan-Meier curve were used to assess potential survival difference between patients undergoing surgery plus perioperative chemotherapy (SA + CT) and those undergoing surgery alone (SA).<h4>Results</h4>In a total of 2,711 EC patients (T1-3N0M0), 166 patients underwent SA + CT and 2,542021-01-01T00:00:00Z2021 Feb2025-04-18T17:47:10.506Z2025-02-19T01:40:28.87ZS-EPMC79475373371757210.21037/jtd-20-2877