{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang M"],"funding":["Tai’shan Scholar Engineering Construction Fund of Shandong Province of China","Shandong University"],"pagination":["647611"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7947916"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["<h4>Background</h4>Dental caries is an acid-related disease. Current anti-caries agents mainly focus on the bacteriostatic effect in a neutral environment and do not target acid-resistant microorganisms related to caries in acidic milieus.<h4>Objectives</h4>To assess the <i>in vitro</i> antibacterial activities of bedaquiline against oral pathogens in acidic milieus.<h4>Methods</h4><i>Streptococcus mutans</i>, <i>Streptococcus sanguinis</i>, and <i>Streptococcus salivarius</i> were used to prepare the mono-/multiple suspension and biofilm. The MIC and IC<sub>50</sub> of bedaquiline against <i>S. mutans</i> were determined by the broth microdilution method. Bedaquiline was compared regarding (i) the inhibitory activity in pH 4-7 and at different time points against planktonic and biofilm; ("],"journal":["Frontiers in microbiology"],"pubmed_title":["<i>In vitro</i> Antibacterial Activity of an FDA-Approved H<sup>+</sup>-ATPase Inhibitor, Bedaquiline, Against <i>Streptococcus mutans</i> in Acidic Milieus."],"pmcid":["PMC7947916"],"funding_grant_id":["2018GN024","TS201511106"],"pubmed_authors":["Zhang D","Zhou S","Yu W","Zhang M","Xu X","Zhang B","Lo ECM"],"additional_accession":[]},"is_claimable":false,"name":"<i>In vitro</i> Antibacterial Activity of an FDA-Approved H<sup>+</sup>-ATPase Inhibitor, Bedaquiline, Against <i>Streptococcus mutans</i> in Acidic Milieus.","description":"<h4>Background</h4>Dental caries is an acid-related disease. Current anti-caries agents mainly focus on the bacteriostatic effect in a neutral environment and do not target acid-resistant microorganisms related to caries in acidic milieus.<h4>Objectives</h4>To assess the <i>in vitro</i> antibacterial activities of bedaquiline against oral pathogens in acidic milieus.<h4>Methods</h4><i>Streptococcus mutans</i>, <i>Streptococcus sanguinis</i>, and <i>Streptococcus salivarius</i> were used to prepare the mono-/multiple suspension and biofilm. The MIC and IC<sub>50</sub> of bedaquiline against <i>S. mutans</i> were determined by the broth microdilution method. Bedaquiline was compared regarding (i) the inhibitory activity in pH 4-7 and at different time points against planktonic and biofilm; (","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-02T16:47:21.782Z","creation":"2021-03-14T08:17:18Z"},"accession":"S-EPMC7947916","cross_references":{"pubmed":["33717046"],"doi":["10.3389/fmicb.2021.647611"]}}