{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20"],"submitter":["Martinez-Huenchullan SF"],"funding":["Cancer Institute NSW","National Health and Medical Research Council"],"pubmed_abstract":["The increasing consumption of high-fat foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the overconsumption of a high-fat diet (HFD) and exercise interact is not well characterized at the molecular level. Here, we examined the plasma proteome in mice for the effects of aerobic exercise as both a treatment and as a preventative regimen for animals on either a HFD or a healthy control diet. This analysis detected large changes in the plasma proteome induced by the HFD, such as increased abundance of SERPINA7, ALDOB, and downregulation of SERPINA1E and complement factor D (CFD; adipsin). Some of these changes were significantly reverted using exercise as a preventa"],"journal":["Molecular & cellular proteomics : MCP"],"pagination":["100027"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7950115"],"repository":["biostudies-literature"],"pubmed_title":["Blockade of High-Fat Diet Proteomic Phenotypes Using Exercise as Prevention or Treatment."],"pmcid":["PMC7950115"],"pubmed_authors":["Larance M","Min D","Twigg SM","Martinez-Huenchullan SF","Hatchwell L","Shipsey I"],"additional_accession":[]},"is_claimable":false,"name":"Blockade of High-Fat Diet Proteomic Phenotypes Using Exercise as Prevention or Treatment.","description":"The increasing consumption of high-fat foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the overconsumption of a high-fat diet (HFD) and exercise interact is not well characterized at the molecular level. Here, we examined the plasma proteome in mice for the effects of aerobic exercise as both a treatment and as a preventative regimen for animals on either a HFD or a healthy control diet. This analysis detected large changes in the plasma proteome induced by the HFD, such as increased abundance of SERPINA7, ALDOB, and downregulation of SERPINA1E and complement factor D (CFD; adipsin). Some of these changes were significantly reverted using exercise as a preventa","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T08:40:08.307Z","creation":"2022-02-10T09:10:15.514Z"},"accession":"S-EPMC7950115","cross_references":{"pubmed":["33594989"],"doi":["10.1074/mcp.TIR120.002343"]}}