{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(4)"],"submitter":["Wang X"],"pubmed_abstract":["Exogenous factors influence embryo development. Enniatin B1 (EB1), one emerging mycotoxin of Fusarium fungi, can cause damage to cells and mouse blastocysts. However, the toxicity of EB1 on porcine embryo development and whether melatonin can eliminate the detrimental effects of EB1 on embryos remain unclear. Here, this work demonstrated that EB1 significantly decreased the cleavage and blastocyst rates and blastocyst cell number of embryos in a dose and time dependent manner. Further study displayed that EB1 obviously destroyed nuclear remodeling dynamics. Importantly, EB1 triggered embryo apoptosis through downregulating the expression of <i>Sod1,</i> <i>Gpx4</i>, <i>Cat</i> and <i>Bcl2l1</i> while upregulating the transcription of <i>Bax</i> and <i>Caspase3</i>. Moreover, EB1 significan"],"journal":["Aging"],"pagination":["5553-5570"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7950273"],"repository":["biostudies-literature"],"pubmed_title":["Melatonin protects against defects induced by Enniatin B1 during porcine early embryo development."],"pmcid":["PMC7950273"],"pubmed_authors":["Sun M","Li J","He H","Huan Y","Wang X","Song X"],"additional_accession":[]},"is_claimable":false,"name":"Melatonin protects against defects induced by Enniatin B1 during porcine early embryo development.","description":"Exogenous factors influence embryo development. Enniatin B1 (EB1), one emerging mycotoxin of Fusarium fungi, can cause damage to cells and mouse blastocysts. However, the toxicity of EB1 on porcine embryo development and whether melatonin can eliminate the detrimental effects of EB1 on embryos remain unclear. Here, this work demonstrated that EB1 significantly decreased the cleavage and blastocyst rates and blastocyst cell number of embryos in a dose and time dependent manner. Further study displayed that EB1 obviously destroyed nuclear remodeling dynamics. Importantly, EB1 triggered embryo apoptosis through downregulating the expression of <i>Sod1,</i> <i>Gpx4</i>, <i>Cat</i> and <i>Bcl2l1</i> while upregulating the transcription of <i>Bax</i> and <i>Caspase3</i>. Moreover, EB1 significan","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-18T23:11:23.892Z","creation":"2025-04-07T10:45:37.802Z"},"accession":"S-EPMC7950273","cross_references":{"pubmed":["33589578"],"doi":["10.18632/aging.202484"]}}