biostudies-literatureWang NYMinistry of Science and Technology, Taiwane0248434https://www.ebi.ac.uk/biostudies/studies/S-EPMC7951916biostudies-literatureUnknown16(3)<h4>Purpose</h4>Reading comprehension is closely associated with word recognition, particularly at the early stage of reading development. This association is reflected in children with reading difficulties (RD) who demonstrate poor reading comprehension along with delayed word recognition or reduced recognition accuracy. Although the neural mechanisms underlying reading comprehension and word recognition are well studied, few has investigated the white matter (WM) structures that the two processes potentially share.<h4>Methods</h4>To explore the issue, behavioral scores (word recognition & reading comprehension) and diffusion spectrum imaging (DSI) were acquired from Chinese-speaking children with RD and their age-matched typically developing children. WM structures were measured with genPloS oneInvestigating the white matter correlates of reading performance: Evidence from Chinese children with reading difficulties.PMC7951916MOST103-2420-H-003-008-MY3MOST107-2221-E-182-054-MY3Weng JCWang NYWang HSChang YELiu YCfalseInvestigating the white matter correlates of reading performance: Evidence from Chinese children with reading difficulties.<h4>Purpose</h4>Reading comprehension is closely associated with word recognition, particularly at the early stage of reading development. This association is reflected in children with reading difficulties (RD) who demonstrate poor reading comprehension along with delayed word recognition or reduced recognition accuracy. Although the neural mechanisms underlying reading comprehension and word recognition are well studied, few has investigated the white matter (WM) structures that the two processes potentially share.<h4>Methods</h4>To explore the issue, behavioral scores (word recognition & reading comprehension) and diffusion spectrum imaging (DSI) were acquired from Chinese-speaking children with RD and their age-matched typically developing children. WM structures were measured with gen2021-01-01T00:00:00Z20212025-04-20T02:30:37.216Z2025-04-20T02:30:37.216ZS-EPMC79519163370549410.1371/journal.pone.0248434