biostudies-literatureUnknown23(2)Li G<h4>Background</h4>The gut microbiome is receiving considerable attention as a potentially modifiable risk factor and therapeutic target for numerous mental and neurological diseases.<h4>Objective</h4>This study aimed to explore and assess the difference in the composition of gut microbes and fecal metabolites between women with hypoactive sexual desire disorder (HSDD) and healthy controls.<h4>Methods</h4>We employed an online recruitment method to enroll "hard-to-reach" HSDD populations. After a stringent diagnostic and exclusion process based on DSM-IV criteria, fecal samples collected from 24 women with HSDD and 22 age-matched, healthy controls underwent microbiome analysis using 16S ribosomal RNA gene sequencing and metabolome analysis using untargeted liquid chromatography-mass spectrJournal of medical Internet researche25342https://www.ebi.ac.uk/biostudies/studies/S-EPMC7952237biostudies-literatureDifferences in the Gut Microbiome of Women With and Without Hypoactive Sexual Desire Disorder: Case Control Study.PMC7952237Li GShen QZhou PSong BWang CXu CWang GTang DWei ZWu HLi WGeng HZhang ZHe XCao YGao YLi BXu XfalseDifferences in the Gut Microbiome of Women With and Without Hypoactive Sexual Desire Disorder: Case Control Study.<h4>Background</h4>The gut microbiome is receiving considerable attention as a potentially modifiable risk factor and therapeutic target for numerous mental and neurological diseases.<h4>Objective</h4>This study aimed to explore and assess the difference in the composition of gut microbes and fecal metabolites between women with hypoactive sexual desire disorder (HSDD) and healthy controls.<h4>Methods</h4>We employed an online recruitment method to enroll "hard-to-reach" HSDD populations. After a stringent diagnostic and exclusion process based on DSM-IV criteria, fecal samples collected from 24 women with HSDD and 22 age-matched, healthy controls underwent microbiome analysis using 16S ribosomal RNA gene sequencing and metabolome analysis using untargeted liquid chromatography-mass spectr2021-01-01T00:00:00Z2021 Feb2025-04-18T16:41:14.003Z2025-04-07T04:04:47.574ZS-EPMC79522373362996410.2196/25342