biostudies-literatureUnknown5(2)Nunez R<h4>Background</h4>A thrombus in transit (TIT) is a life-threatening condition associated with pulmonary embolism (PE). While TIT was once considered a rare diagnosis, its emergence has risen in recent years mainly through advancement in medical technology. Rare cases of a thrombus in transit crossing a patent foramen ovale in the context of pulmonary embolism have been reported. The appropriate treatment of patients in this setting remains unclear.<h4>Case summary</h4>We describe a 64-year-old man who presented with syncope to the emergency room secondary to acute pulmonary embolism. Initial transthoracic echocardiogram revealed a large intracardiac thrombus in transit across a patent foramen ovale, verified by transoesophageal echocardiogram. He underwent anticoagulation and urgent surgiEuropean heart journal. Case reportsytaa580https://www.ebi.ac.uk/biostudies/studies/S-EPMC7954258biostudies-literatureCase report: Thrombus in transit-a cause of impending paradoxical embolism.PMC7954258Nunez JGBerber SNunez RSanchez JALoaiza FAlmeida EArias SfalseCase report: Thrombus in transit-a cause of impending paradoxical embolism.<h4>Background</h4>A thrombus in transit (TIT) is a life-threatening condition associated with pulmonary embolism (PE). While TIT was once considered a rare diagnosis, its emergence has risen in recent years mainly through advancement in medical technology. Rare cases of a thrombus in transit crossing a patent foramen ovale in the context of pulmonary embolism have been reported. The appropriate treatment of patients in this setting remains unclear.<h4>Case summary</h4>We describe a 64-year-old man who presented with syncope to the emergency room secondary to acute pulmonary embolism. Initial transthoracic echocardiogram revealed a large intracardiac thrombus in transit across a patent foramen ovale, verified by transoesophageal echocardiogram. He underwent anticoagulation and urgent surgi2021-01-01T00:00:00Z2021 Feb2025-04-05T16:17:52.842Z2025-04-05T16:17:52.842ZS-EPMC79542583373841410.1093/ehjcr/ytaa580