{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rooney MR"],"funding":["NHLBI NIH HHS","National Heart, Lung, and Blood Institute"],"pagination":["106248"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7954896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["101"],"pubmed_abstract":["The Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) randomized clinical trial was conducted in adults with type 2 diabetes and moderate-to-severe obstructive sleep apnea (OSA) to determine whether treatment with positive airway pressure (PAP) therapy is associated with improvements in glycemic measures. Participants were randomly assigned to PAP therapy with lifestyle counseling or lifestyle counseling alone. While observational and experimental evidence indicate that intermittent hypoxemia and recurrent arousals in OSA may alter glucose metabolism and worsen glycemic measures, the effect of treating OSA with PAP therapy on these measures in type 2 diabetes is uncertain. Adequately powered randomized clinical trials have yet to be performed to demonstrate whether PAP therapy for"],"journal":["Contemporary clinical trials"],"pubmed_title":["Rationale and design of the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial."],"pmcid":["PMC7954896"],"funding_grant_id":["R01 HL117167","K24 HL152440","R01HL117167","R01 HL146709","T32 HL007024","K23 HL118414","T32HL007024","K23HL118414","K24HL152440"],"pubmed_authors":["Aurora RN","Punjabi NM","Selvin E","Wang D","Rooney MR"],"additional_accession":[]},"is_claimable":false,"name":"Rationale and design of the Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) trial.","description":"The Hyperglycemic Profiles in Obstructive Sleep Apnea (HYPNOS) randomized clinical trial was conducted in adults with type 2 diabetes and moderate-to-severe obstructive sleep apnea (OSA) to determine whether treatment with positive airway pressure (PAP) therapy is associated with improvements in glycemic measures. Participants were randomly assigned to PAP therapy with lifestyle counseling or lifestyle counseling alone. While observational and experimental evidence indicate that intermittent hypoxemia and recurrent arousals in OSA may alter glucose metabolism and worsen glycemic measures, the effect of treating OSA with PAP therapy on these measures in type 2 diabetes is uncertain. Adequately powered randomized clinical trials have yet to be performed to demonstrate whether PAP therapy for","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-19T23:32:45.611Z","creation":"2022-02-11T15:46:00.31Z"},"accession":"S-EPMC7954896","cross_references":{"pubmed":["33316455"],"doi":["10.1016/j.cct.2020.106248"]}}