biostudies-literatureVaidya VRNHLBI NIH HHSe015563https://www.ebi.ac.uk/biostudies/studies/S-EPMC7955291biostudies-literatureUnknown10(2)Background The prognosis of left ventricular noncompaction (LVNC) remains elusive despite its recognition as a clinical entity for >30 years. We sought to identify clinical and imaging characteristics and risk factors for mortality in patients with LVNC. Methods and Results 339 adults with LVNC seen between 2000 and 2016 were identified. LVNC was defined as end-systolic noncompacted to compacted myocardial ratio >2 (Jenni criteria) and end-diastolic trough of trabeculation-to-epicardium (X):peak of trabeculation-to-epicardium (Y) ratio <0.5 (Chin criteria) by echocardiography; and end-diastolic noncompacted:compacted ratio >2.3 (Petersen criteria) by magnetic resonance imaging. Median age was 47.4 years, and 46% of patients were female. Left ventricular ejection fraction <50% was present iJournal of the American Heart AssociationLong-Term Survival of Patients With Left Ventricular Noncompaction.PMC7955291K01 HL135288Michelena HIConnolly HMFoley TAFarwati MPatlolla SHMelduni RMAsirvatham SJMiranda WRHodge DOVaidya VRKapa SIsath ADeshmukh AJLyle MfalseLong-Term Survival of Patients With Left Ventricular Noncompaction.Background The prognosis of left ventricular noncompaction (LVNC) remains elusive despite its recognition as a clinical entity for >30 years. We sought to identify clinical and imaging characteristics and risk factors for mortality in patients with LVNC. Methods and Results 339 adults with LVNC seen between 2000 and 2016 were identified. LVNC was defined as end-systolic noncompacted to compacted myocardial ratio >2 (Jenni criteria) and end-diastolic trough of trabeculation-to-epicardium (X):peak of trabeculation-to-epicardium (Y) ratio <0.5 (Chin criteria) by echocardiography; and end-diastolic noncompacted:compacted ratio >2.3 (Petersen criteria) by magnetic resonance imaging. Median age was 47.4 years, and 46% of patients were female. Left ventricular ejection fraction <50% was present i2021-01-01T00:00:00Z2021 Jan2025-04-05T13:48:36.793Z2025-04-05T13:48:36.793ZS-EPMC79552913344102910.1161/JAHA.119.015563