{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uhlorn JA"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS"],"pagination":["e018038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7955317"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(2)"],"pubmed_abstract":["Background Menopause is associated with an increase in the prevalence and severity of hypertension in women. Although premenopausal females are protected against T cell-dependent immune activation and development of angiotensin II (Ang II) hypertension, this protection is lost in postmenopausal females. Therefore, the current study hypothesized that specific CD4<sup>+</sup> T cell pathways are regulated by sex hormones and Ang II to mediate progression from premenopausal protection to postmenopausal hypertension. Methods and Results Menopause was induced in C57BL/6 mice via repeated 4-vinylcyclohexene diepoxide injections, while premenopausal females received sesame oil vehicle. A subset of premenopausal mice and all menopausal mice were infused with Ang II for 14 days (Control, Ang II, Me"],"journal":["Journal of the American Heart Association"],"pubmed_title":["CD4<sup>+</sup> T Cell-Specific Proteomic Pathways Identified in Progression of Hypertension Across Postmenopausal Transition."],"pmcid":["PMC7955317"],"funding_grant_id":["T32 HL007249","R01 HL131834","R01 DK098493"],"pubmed_authors":["Moffett C","Husband NA","Uhlorn JA","Lindsey ML","Langlais PR","Romero-Aleshire MJ","Brooks HL"],"additional_accession":[]},"is_claimable":false,"name":"CD4<sup>+</sup> T Cell-Specific Proteomic Pathways Identified in Progression of Hypertension Across Postmenopausal Transition.","description":"Background Menopause is associated with an increase in the prevalence and severity of hypertension in women. Although premenopausal females are protected against T cell-dependent immune activation and development of angiotensin II (Ang II) hypertension, this protection is lost in postmenopausal females. Therefore, the current study hypothesized that specific CD4<sup>+</sup> T cell pathways are regulated by sex hormones and Ang II to mediate progression from premenopausal protection to postmenopausal hypertension. Methods and Results Menopause was induced in C57BL/6 mice via repeated 4-vinylcyclohexene diepoxide injections, while premenopausal females received sesame oil vehicle. A subset of premenopausal mice and all menopausal mice were infused with Ang II for 14 days (Control, Ang II, Me","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jan","modification":"2026-04-18T01:04:23.148Z","creation":"2024-12-03T16:37:59.056Z"},"accession":"S-EPMC7955317","cross_references":{"pubmed":["33410333"],"doi":["10.1161/JAHA.120.018038"]}}