{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(24)"],"submitter":["Frati G"],"pubmed_abstract":["Background The role of microRNAs dysregulation in tobacco cigarette smoking-induced vascular damage still needs to be clarified. We assessed the acute effects of tobacco cigarette smoking on endothelial cell-related circulating microRNAs in healthy subjects. In addition, we investigated the potential role of microRNAs in smoking-dependent endothelial cell damage. Methods and Results A panel of endothelial-related microRNAs was quantified in healthy subjects before and after smoking 1 tobacco cigarette. Serum levels of miR-155 were found to be significantly increased shortly after smoking. We also observed a progressive and significant miR-155 accumulation in culture media of human endothelial cells after 30 minutes and up to 4 hours of cigarette smoke condensate treatment in vitro without "],"journal":["Journal of the American Heart Association"],"pagination":["e017000"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7955400"],"repository":["biostudies-literature"],"pubmed_title":["Inhibition of miR-155 Attenuates Detrimental Vascular Effects of Tobacco Cigarette Smoking."],"pmcid":["PMC7955400"],"pubmed_authors":["di Nonno F","Versaci F","De Falco E","Nocella C","Sciarretta S","Bianchi F","Carnevale R","Cavarretta E","Picchio V","Stanzione R","Marchitti S","Schiavon S","Rubattu S","Vecchio D","Chimenti I","Frati G","Bordin A","Pagano F","Paneni F","Forte M","Volpe M","Biondi-Zoccai G"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of miR-155 Attenuates Detrimental Vascular Effects of Tobacco Cigarette Smoking.","description":"Background The role of microRNAs dysregulation in tobacco cigarette smoking-induced vascular damage still needs to be clarified. We assessed the acute effects of tobacco cigarette smoking on endothelial cell-related circulating microRNAs in healthy subjects. In addition, we investigated the potential role of microRNAs in smoking-dependent endothelial cell damage. Methods and Results A panel of endothelial-related microRNAs was quantified in healthy subjects before and after smoking 1 tobacco cigarette. Serum levels of miR-155 were found to be significantly increased shortly after smoking. We also observed a progressive and significant miR-155 accumulation in culture media of human endothelial cells after 30 minutes and up to 4 hours of cigarette smoke condensate treatment in vitro without ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-21T17:03:17.6Z","creation":"2025-04-21T17:03:17.6Z"},"accession":"S-EPMC7955400","cross_references":{"pubmed":["33317369"],"doi":["10.1161/JAHA.120.017000"]}}