{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(3)"],"submitter":["Morello F"],"pubmed_abstract":["Background When acute aortic syndromes (AASs) are suspected, pretest clinical probability assessment and d-dimer (DD) testing are diagnostic options allowing standardized care. Guidelines suggest use of a 12-item/3-category score (aortic dissection detection) and a DD cutoff of 500 ng/mL. However, a simplified assessment tool and a more specific DD cutoff could be advantageous. Methods and Results In a prospective derivation cohort (n=1848), 6 items identified by logistic regression (thoracic aortic aneurysm, severe pain, sudden pain, pulse deficit, neurologic deficit, hypotension), composed a simplified score (AORTAs) assigning 2 points to hypotension and 1 to the other items. AORTAs≤1 and ≥2 defined low and high clinical probability, respectively. Age-adjusted DD was calculated as years/"],"journal":["Journal of the American Heart Association"],"pagination":["e018425"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7955418"],"repository":["biostudies-literature"],"pubmed_title":["Development and Validation of a Simplified Probability Assessment Score Integrated With Age-Adjusted d-Dimer for Diagnosis of Acute Aortic Syndromes."],"pmcid":["PMC7955418"],"pubmed_authors":["Nazerian P","Casanova B","Catini E","Mueller C","Nestelberger T","Bima P","Pivetta E","Santoro M","de Matos Soeiro A","Grifoni S","Lupia E","Morello F","Leidel BA"],"additional_accession":[]},"is_claimable":false,"name":"Development and Validation of a Simplified Probability Assessment Score Integrated With Age-Adjusted d-Dimer for Diagnosis of Acute Aortic Syndromes.","description":"Background When acute aortic syndromes (AASs) are suspected, pretest clinical probability assessment and d-dimer (DD) testing are diagnostic options allowing standardized care. Guidelines suggest use of a 12-item/3-category score (aortic dissection detection) and a DD cutoff of 500 ng/mL. However, a simplified assessment tool and a more specific DD cutoff could be advantageous. Methods and Results In a prospective derivation cohort (n=1848), 6 items identified by logistic regression (thoracic aortic aneurysm, severe pain, sudden pain, pulse deficit, neurologic deficit, hypotension), composed a simplified score (AORTAs) assigning 2 points to hypotension and 1 to the other items. AORTAs≤1 and ≥2 defined low and high clinical probability, respectively. Age-adjusted DD was calculated as years/","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-18T16:40:16.84Z","creation":"2025-04-07T04:01:25.474Z"},"accession":"S-EPMC7955418","cross_references":{"pubmed":["33474974"],"doi":["10.1161/JAHA.120.018425"]}}