{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang D"],"funding":["Anhui provincial laboratory of internal medicine application and development of modern Chinese medicine","Construction project of Jian Liu studio of TCM in Anhui province","National key research and development program of the ministry of science and technology"],"pagination":["272"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7955637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Background
Ankylosing spondylitis (AS) is a chronic autoimmune disease affecting the sacroiliac joint. To date, few studies have examined the association between long non-coding RNAs (lncRNAs) and AS pathogenesis. As such, we herein sought to characterize patterns of AS-related lncRNA expression and to evaluate the potential role played by these lncRNAs in this complex autoimmune context.Methods
We conducted a RNA-seq analysis of peripheral blood mononuclear cell (PBMC) samples isolated from five AS patients and corresponding controls. These data were then leveraged to characterize AS-related lncRNA expression patterns. We further conducted GO and KEGG enrichment analyses of the parental genes encoding these lncRNAs, and we confirmed the validity of our RNA-seq data by asse"],"journal":["BMC musculoskeletal disorders"],"pubmed_title":["Identification of lncRNAs associated with the pathogenesis of ankylosing spondylitis."],"pmcid":["PMC7955637"],"funding_grant_id":["secretary of development of traditional Chinese medicine [2018] no. 11","2016080503B041","2018YFC1705204"],"pubmed_authors":["Fang Y","Liu J","Huang D","Long Y","Zhang Y","Wan L","Bao B"],"additional_accession":[]},"is_claimable":false,"name":"Identification of lncRNAs associated with the pathogenesis of ankylosing spondylitis.","description":"Background
Ankylosing spondylitis (AS) is a chronic autoimmune disease affecting the sacroiliac joint. To date, few studies have examined the association between long non-coding RNAs (lncRNAs) and AS pathogenesis. As such, we herein sought to characterize patterns of AS-related lncRNA expression and to evaluate the potential role played by these lncRNAs in this complex autoimmune context.Methods
We conducted a RNA-seq analysis of peripheral blood mononuclear cell (PBMC) samples isolated from five AS patients and corresponding controls. These data were then leveraged to characterize AS-related lncRNA expression patterns. We further conducted GO and KEGG enrichment analyses of the parental genes encoding these lncRNAs, and we confirmed the validity of our RNA-seq data by asse","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T11:36:48.711Z","creation":"2025-02-19T01:05:56.662Z"},"accession":"S-EPMC7955637","cross_references":{"pubmed":["33711974"],"doi":["10.1186/s12891-021-04119-6"]}}