biostudies-literatureHuang DAnhui provincial laboratory of internal medicine application and development of modern Chinese medicineConstruction project of Jian Liu studio of TCM in Anhui provinceNational key research and development program of the ministry of science and technology272https://www.ebi.ac.uk/biostudies/studies/S-EPMC7955637biostudies-literatureUnknown22(1)<h4>Background</h4>Ankylosing spondylitis (AS) is a chronic autoimmune disease affecting the sacroiliac joint. To date, few studies have examined the association between long non-coding RNAs (lncRNAs) and AS pathogenesis. As such, we herein sought to characterize patterns of AS-related lncRNA expression and to evaluate the potential role played by these lncRNAs in this complex autoimmune context.<h4>Methods</h4>We conducted a RNA-seq analysis of peripheral blood mononuclear cell (PBMC) samples isolated from five AS patients and corresponding controls. These data were then leveraged to characterize AS-related lncRNA expression patterns. We further conducted GO and KEGG enrichment analyses of the parental genes encoding these lncRNAs, and we confirmed the validity of our RNA-seq data by asseBMC musculoskeletal disordersIdentification of lncRNAs associated with the pathogenesis of ankylosing spondylitis.PMC7955637secretary of development of traditional Chinese medicine [2018] no. 112016080503B0412018YFC1705204Fang YLiu JHuang DLong YZhang YWan LBao BfalseIdentification of lncRNAs associated with the pathogenesis of ankylosing spondylitis.<h4>Background</h4>Ankylosing spondylitis (AS) is a chronic autoimmune disease affecting the sacroiliac joint. To date, few studies have examined the association between long non-coding RNAs (lncRNAs) and AS pathogenesis. As such, we herein sought to characterize patterns of AS-related lncRNA expression and to evaluate the potential role played by these lncRNAs in this complex autoimmune context.<h4>Methods</h4>We conducted a RNA-seq analysis of peripheral blood mononuclear cell (PBMC) samples isolated from five AS patients and corresponding controls. These data were then leveraged to characterize AS-related lncRNA expression patterns. We further conducted GO and KEGG enrichment analyses of the parental genes encoding these lncRNAs, and we confirmed the validity of our RNA-seq data by asse2021-01-01T00:00:00Z2021 Mar2025-04-04T11:36:48.711Z2025-02-19T01:05:56.662ZS-EPMC79556373371197410.1186/s12891-021-04119-6