{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li KP"],"funding":["National Natural Science Foundation of China"],"pagination":["6617586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7955866"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2021"],"pubmed_abstract":["The progressive increase of metabolic diseases underscores the necessity for developing effective therapies. Although we found Tian-Huang formula (THF) could alleviate metabolic disorders, the underlying mechanism remains to be fully understood. In the present study, firstly, male Sprague-Dawley rats were fed with high-fat diet plus high-fructose drink (HFF, the diet is about 60% of calories from fat and the drink is 12.5% fructose solution) for 14 weeks to induce hepatosteatosis and glucose intolerance and then treated with THF (200 mg/kg) for 4 weeks. Then, metabolomics analysis was performed with rat liver samples and following the clues illustrated by Ingenuity Pathway Analysis (IPA) with the metabolomics discoveries, RT-qPCR and Western blotting were carried out to validate the putati"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats."],"pmcid":["PMC7955866"],"funding_grant_id":["81530102","2019B030302005","2020KTSCX058"],"pubmed_authors":["Guo J","Li KP","Rong XL","Turnbull JE","Yuan M","Zhang CM","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Tian-Huang Formula, a Traditional Chinese Medicinal Prescription, Improves Hepatosteatosis and Glucose Intolerance Targeting AKT-SREBP Nexus in Diet-Induced Obese Rats.","description":"The progressive increase of metabolic diseases underscores the necessity for developing effective therapies. Although we found Tian-Huang formula (THF) could alleviate metabolic disorders, the underlying mechanism remains to be fully understood. In the present study, firstly, male Sprague-Dawley rats were fed with high-fat diet plus high-fructose drink (HFF, the diet is about 60% of calories from fat and the drink is 12.5% fructose solution) for 14 weeks to induce hepatosteatosis and glucose intolerance and then treated with THF (200 mg/kg) for 4 weeks. Then, metabolomics analysis was performed with rat liver samples and following the clues illustrated by Ingenuity Pathway Analysis (IPA) with the metabolomics discoveries, RT-qPCR and Western blotting were carried out to validate the putati","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-18T13:54:24.646Z","creation":"2025-04-06T23:45:17.471Z"},"accession":"S-EPMC7955866","cross_references":{"pubmed":["33763145"],"doi":["10.1155/2021/6617586"]}}