{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["He C"],"pubmed_abstract":["<h4>Background</h4>Cancer patients are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than the general population, with lung epithelial cells or enterocytes being the main targets. However, the expressions of SARS-CoV-2 entry-related genes in aerodigestive cancers have not been fully elucidated.<h4>Methods</h4>In this study, the expressions of SARS-CoV-2 receptors and cofactors, including angiotensin I-converting enzyme 2 (ACE2), basigin (BSG) and transmembrane serine protease 2 (TMPRSS2), were comprehensively assessed. We compared BSG and TMPRSS2 expressions between aerodigestive cancers and matched normal tissues through Gene Expression Profiling Interactive Analysis 2 (GEPIA2). Furthermore, expressions in healthy colon tissues at different anat"],"journal":["Journal of inflammation research"],"pagination":["791-802"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7956868"],"repository":["biostudies-literature"],"pubmed_title":["Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers."],"pmcid":["PMC7956868"],"pubmed_authors":["Hua X","He C","Li S","Sun S","Huang X","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers.","description":"<h4>Background</h4>Cancer patients are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection than the general population, with lung epithelial cells or enterocytes being the main targets. However, the expressions of SARS-CoV-2 entry-related genes in aerodigestive cancers have not been fully elucidated.<h4>Methods</h4>In this study, the expressions of SARS-CoV-2 receptors and cofactors, including angiotensin I-converting enzyme 2 (ACE2), basigin (BSG) and transmembrane serine protease 2 (TMPRSS2), were comprehensively assessed. We compared BSG and TMPRSS2 expressions between aerodigestive cancers and matched normal tissues through Gene Expression Profiling Interactive Analysis 2 (GEPIA2). Furthermore, expressions in healthy colon tissues at different anat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-03T21:32:35.538Z","creation":"2025-04-03T21:32:35.538Z"},"accession":"S-EPMC7956868","cross_references":{"pubmed":["33732005"],"doi":["10.2147/JIR.S300127"]}}