{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Valdes Hernandez MDC"],"funding":["Medical Research Council","Wellcome Trust","Mrs Gladys Row Fogo Charitable Trust"],"pagination":["634460"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7956970"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Lacunar strokes are a common type of ischemic stroke. They are known to have long-term cognitive deficits, but the influencing factors are still largely unknown. We investigated if the location of the index lacunar stroke or regional WMH and their change at 1 year could predict the cognitive performance at 1 and 3 years post-stroke in lacunar stroke patients. We used lacunar lesion location and WMH-segmented data from 118 patients, mean age 64.9 who had a brain MRI scan soon after presenting with symptoms, of which 88 had a repeated scan 12 months later. Premorbid intelligence (National Adult Reading Test) and current intelligence [Addenbrooke's Cognitive Exam-Revised (ACE-R)] were measured at 1, 12, and 36 months after the stroke. ANCOVA analyses adjusting for baseline cognition/premorbid"],"journal":["Frontiers in neurology"],"pubmed_title":["Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke."],"pmcid":["PMC7956970"],"funding_grant_id":["UKDRI-4002","WT088134/Z/09/A"],"pubmed_authors":["Makin S","Grimsley-Moore T","Chappell FM","Sakka E","Wardlaw JM","Valdes Hernandez MDC","Thrippleton MJ","Armitage PA"],"additional_accession":[]},"is_claimable":false,"name":"Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke.","description":"Lacunar strokes are a common type of ischemic stroke. They are known to have long-term cognitive deficits, but the influencing factors are still largely unknown. We investigated if the location of the index lacunar stroke or regional WMH and their change at 1 year could predict the cognitive performance at 1 and 3 years post-stroke in lacunar stroke patients. We used lacunar lesion location and WMH-segmented data from 118 patients, mean age 64.9 who had a brain MRI scan soon after presenting with symptoms, of which 88 had a repeated scan 12 months later. Premorbid intelligence (National Adult Reading Test) and current intelligence [Addenbrooke's Cognitive Exam-Revised (ACE-R)] were measured at 1, 12, and 36 months after the stroke. ANCOVA analyses adjusting for baseline cognition/premorbid","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-04T13:13:37.279Z","creation":"2025-04-04T13:13:37.279Z"},"accession":"S-EPMC7956970","cross_references":{"pubmed":["33732208"],"doi":["10.3389/fneur.2021.634460"]}}