biostudies-literatureUnknown35(3)Zhang A<h4>Background</h4>This study investigated the clinical implication of TNK2 expression in esophageal cancer patients' cancer tissue samples.<h4>Methods</h4>The expression of TNK2 in esophageal cancer tissues and para-carcinoma tissue was assessed with immunohistochemistry and Western blot analysis; besides, the proteins of CDC42, EGFR, and Akt were also analyzed. Then, Kaplan-Meier survival curves of TNK2 protein expression level were assayed with 184 esophageal cancer patients from TCGA database. Moreover, with multiple linear regression analysis, we detected the correlations of TNK2 expression associated with tumor differentiation degree and metastasis status.<h4>Results</h4>It revealed that TNK2 was highly expressed in the cytoplasm of esophageal cancer tissues compared with para-carcinJournal of clinical laboratory analysise23700https://www.ebi.ac.uk/biostudies/studies/S-EPMC7958005biostudies-literatureTNK2 promoted esophageal cancer progression via activating egfr-akt signaling.PMC7958005Yang ZTian RZhang RZhang AfalseTNK2 promoted esophageal cancer progression via activating egfr-akt signaling.<h4>Background</h4>This study investigated the clinical implication of TNK2 expression in esophageal cancer patients' cancer tissue samples.<h4>Methods</h4>The expression of TNK2 in esophageal cancer tissues and para-carcinoma tissue was assessed with immunohistochemistry and Western blot analysis; besides, the proteins of CDC42, EGFR, and Akt were also analyzed. Then, Kaplan-Meier survival curves of TNK2 protein expression level were assayed with 184 esophageal cancer patients from TCGA database. Moreover, with multiple linear regression analysis, we detected the correlations of TNK2 expression associated with tumor differentiation degree and metastasis status.<h4>Results</h4>It revealed that TNK2 was highly expressed in the cytoplasm of esophageal cancer tissues compared with para-carcin2021-01-01T00:00:00Z2021 Mar2025-04-19T15:38:18.684Z2025-04-19T15:38:18.684ZS-EPMC79580053348447210.1002/jcla.23700