{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jeusset LM"],"funding":["CancerCare Manitoba Foundation","Research Manitoba","Canadian Institutes of Health Research","CIHR"],"pagination":["1043"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7958346"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["Chromosome instability (CIN) is an enabling feature of oncogenesis associated with poor patient outcomes, whose genetic determinants remain largely unknown. As mitotic chromatin compaction defects can compromise the accuracy of chromosome segregation into daughter cells and drive CIN, characterizing the molecular mechanisms ensuring accurate chromatin compaction may identify novel CIN genes. In vitro, histone H2B monoubiquitination at lysine 120 (H2Bub1) impairs chromatin compaction, while in vivo H2Bub1 is rapidly depleted from chromatin upon entry into mitosis, suggesting that H2Bub1 removal may be a pre-requisite for mitotic fidelity. The deubiquitinating enzyme USP22 catalyzes H2Bub1 removal in interphase and may also be required for H2Bub1 removal in early mitosis to maintain chromoso"],"journal":["Cancers"],"pubmed_title":["Reduced <i>USP22</i> Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis."],"pmcid":["PMC7958346"],"funding_grant_id":["-","162374"],"pubmed_authors":["Guppy BJ","McDonald D","McManus KJ","Lichtensztejn Z","Jeusset LM"],"additional_accession":[]},"is_claimable":false,"name":"Reduced <i>USP22</i> Expression Impairs Mitotic Removal of H2B Monoubiquitination, Alters Chromatin Compaction and Induces Chromosome Instability That May Promote Oncogenesis.","description":"Chromosome instability (CIN) is an enabling feature of oncogenesis associated with poor patient outcomes, whose genetic determinants remain largely unknown. As mitotic chromatin compaction defects can compromise the accuracy of chromosome segregation into daughter cells and drive CIN, characterizing the molecular mechanisms ensuring accurate chromatin compaction may identify novel CIN genes. In vitro, histone H2B monoubiquitination at lysine 120 (H2Bub1) impairs chromatin compaction, while in vivo H2Bub1 is rapidly depleted from chromatin upon entry into mitosis, suggesting that H2Bub1 removal may be a pre-requisite for mitotic fidelity. The deubiquitinating enzyme USP22 catalyzes H2Bub1 removal in interphase and may also be required for H2Bub1 removal in early mitosis to maintain chromoso","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2026-05-09T11:20:58.685Z","creation":"2021-03-18T08:36:35Z"},"accession":"S-EPMC7958346","cross_references":{"pubmed":["33801331"],"doi":["10.3390/cancers13051043"]}}