{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yao C"],"funding":["NCATS NIH HHS","NHLBI NIH HHS"],"pagination":["707-717"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7958503"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["203(6)"],"pubmed_abstract":["<b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Accelerated aging, loss of epithelial progenitor cell function and/or numbers, and cellular senescence are implicated in the pathogenies of IPF.<b>Objectives:</b> We sought to investigate the role of alveolar type 2 (AT2) cellular senescence in initiation and/or progression of pulmonary fibrosis and therapeutic potential of targeting senescence-related pathways and senescent cells.<b>Methods:</b> Epithelial cells of 9 control donor proximal and distal lung tissues and 11 IPF fibrotic lung tissues were profiled by single-cell RNA sequencing to assesses the contribution of epithelial cells to the senescent cell fraction for IPF. A novel mouse"],"journal":["American journal of respiratory and critical care medicine"],"pubmed_title":["Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis."],"pmcid":["PMC7958503"],"funding_grant_id":["KL2 TR001882","K08 HL141590","R01 HL135163","U01 HL110967","P01 HL108793","T32 HL134637"],"pubmed_authors":["Chen P","Parimon T","Huang G","David G","Noble PW","Liu X","Carraro G","Weigt SS","Stripp BR","Guan X","Soukiasian HJ","Belperio JA","Yao C","Mulay A","Jiang D"],"additional_accession":[]},"is_claimable":false,"name":"Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.","description":"<b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Accelerated aging, loss of epithelial progenitor cell function and/or numbers, and cellular senescence are implicated in the pathogenies of IPF.<b>Objectives:</b> We sought to investigate the role of alveolar type 2 (AT2) cellular senescence in initiation and/or progression of pulmonary fibrosis and therapeutic potential of targeting senescence-related pathways and senescent cells.<b>Methods:</b> Epithelial cells of 9 control donor proximal and distal lung tissues and 11 IPF fibrotic lung tissues were profiled by single-cell RNA sequencing to assesses the contribution of epithelial cells to the senescent cell fraction for IPF. A novel mouse","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-04T19:53:40.415Z","creation":"2025-04-04T19:53:40.415Z"},"accession":"S-EPMC7958503","cross_references":{"pubmed":["32991815"],"doi":["10.1164/rccm.202004-1274OC","10.1164/rccm.202004-1274oc"]}}