biostudies-literatureYao CNCATS NIH HHSNHLBI NIH HHS707-717https://www.ebi.ac.uk/biostudies/studies/S-EPMC7958503biostudies-literatureUnknown203(6)<b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Accelerated aging, loss of epithelial progenitor cell function and/or numbers, and cellular senescence are implicated in the pathogenies of IPF.<b>Objectives:</b> We sought to investigate the role of alveolar type 2 (AT2) cellular senescence in initiation and/or progression of pulmonary fibrosis and therapeutic potential of targeting senescence-related pathways and senescent cells.<b>Methods:</b> Epithelial cells of 9 control donor proximal and distal lung tissues and 11 IPF fibrotic lung tissues were profiled by single-cell RNA sequencing to assesses the contribution of epithelial cells to the senescent cell fraction for IPF. A novel mouseAmerican journal of respiratory and critical care medicineSenescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.PMC7958503KL2 TR001882K08 HL141590R01 HL135163U01 HL110967P01 HL108793T32 HL134637Chen PParimon THuang GDavid GNoble PWLiu XCarraro GWeigt SSStripp BRGuan XSoukiasian HJBelperio JAYao CMulay AJiang DfalseSenescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.<b>Rationale:</b> Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Accelerated aging, loss of epithelial progenitor cell function and/or numbers, and cellular senescence are implicated in the pathogenies of IPF.<b>Objectives:</b> We sought to investigate the role of alveolar type 2 (AT2) cellular senescence in initiation and/or progression of pulmonary fibrosis and therapeutic potential of targeting senescence-related pathways and senescent cells.<b>Methods:</b> Epithelial cells of 9 control donor proximal and distal lung tissues and 11 IPF fibrotic lung tissues were profiled by single-cell RNA sequencing to assesses the contribution of epithelial cells to the senescent cell fraction for IPF. A novel mouse2021-01-01T00:00:00Z2021 Mar2025-04-04T19:53:40.415Z2025-04-04T19:53:40.415ZS-EPMC79585033299181510.1164/rccm.202004-1274OC10.1164/rccm.202004-1274oc