{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(2)"],"submitter":["Chang J"],"pubmed_abstract":["<h4>Introduction</h4>This study aimed to explore the biological functions of <i>AKAP12</i> in lung adenocarcinoma and investigate the interaction between <i>AKAP12</i> and miR-338-3p.<h4>Material and methods</h4>Sixty-one differentially expressed genes in lung adenocarcinoma and adjacent normal tissues were first analyzed by TCGA. Immunohistochemistry and quantitative reverse transcription PCR (qRT-PCR) were further utilized to confirm aberrant <i>AKAP12</i> expression in tumor tissues. The influences of <i>AKAP12</i> on proliferation, invasion and migration, and apoptosis of lung adenocarcinoma were investigated by clone formation assay and MTT assay, transwell assay, and flow cytometry analysis respectively. TargetScan and miRanda databases predicted the binding sites of miRNAs on <i>AKA"],"journal":["Archives of medical science : AMS"],"pagination":["462-473"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7959095"],"repository":["biostudies-literature"],"pubmed_title":["MiR-338-3p improved lung adenocarcinoma by <i>AKAP12</i> suppression."],"pmcid":["PMC7959095"],"pubmed_authors":["Huo Z","Zhang H","Liu S","Li B","Wang X","Chang J"],"additional_accession":[]},"is_claimable":false,"name":"MiR-338-3p improved lung adenocarcinoma by <i>AKAP12</i> suppression.","description":"<h4>Introduction</h4>This study aimed to explore the biological functions of <i>AKAP12</i> in lung adenocarcinoma and investigate the interaction between <i>AKAP12</i> and miR-338-3p.<h4>Material and methods</h4>Sixty-one differentially expressed genes in lung adenocarcinoma and adjacent normal tissues were first analyzed by TCGA. Immunohistochemistry and quantitative reverse transcription PCR (qRT-PCR) were further utilized to confirm aberrant <i>AKAP12</i> expression in tumor tissues. The influences of <i>AKAP12</i> on proliferation, invasion and migration, and apoptosis of lung adenocarcinoma were investigated by clone formation assay and MTT assay, transwell assay, and flow cytometry analysis respectively. TargetScan and miRanda databases predicted the binding sites of miRNAs on <i>AKA","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-26T00:42:32.061Z","creation":"2025-04-06T09:47:10.265Z"},"accession":"S-EPMC7959095","cross_references":{"pubmed":["33747281"],"doi":["10.5114/aoms.2019.90913"]}}