biostudies-literatureUnknownGuo HUC Berkeley Superfund Research ProgramRecent evidence has accumulated that the immune system is intimately intertwined with cancer development. Two key characteristics of carcinogens in which the immune system plays a central role are chronic inflammation and immunosuppression. In this systematic review, we investigated the association of chronic inflammatory and immunosuppressive outcomes with benzene, a widely used industrial chemical. Benzene has been confirmed to cause acute myeloid leukaemia and suspected to cause non-Hodgkin lymphoma, two cancers of the blood-forming system that affect immune cells. We systematically searched PubMed and Embase for all relevant studies using a combination of Medical Subject Headings (MeSH) and selected key words. The detailed review protocol, including search strategy, was registered withOccupational and environmental medicineoemed-2020-106517https://www.ebi.ac.uk/biostudies/studies/S-EPMC7960562biostudies-literatureBenzene-associated immunosuppression and chronic inflammation in humans: a systematic review.PMC7960562P42ES004705Guo HZhang LAhn SfalseBenzene-associated immunosuppression and chronic inflammation in humans: a systematic review.Recent evidence has accumulated that the immune system is intimately intertwined with cancer development. Two key characteristics of carcinogens in which the immune system plays a central role are chronic inflammation and immunosuppression. In this systematic review, we investigated the association of chronic inflammatory and immunosuppressive outcomes with benzene, a widely used industrial chemical. Benzene has been confirmed to cause acute myeloid leukaemia and suspected to cause non-Hodgkin lymphoma, two cancers of the blood-forming system that affect immune cells. We systematically searched PubMed and Embase for all relevant studies using a combination of Medical Subject Headings (MeSH) and selected key words. The detailed review protocol, including search strategy, was registered with2020-01-01T00:00:00Z2020 Sep2025-04-18T12:20:08.223Z2025-04-06T21:53:57.661ZS-EPMC79605623293875610.1136/oemed-2020-106517