biostudies-literatureUnknownDhavalikar PNational Institutes of HealthNIAMS NIH HHSNIH HHSNational Science FoundationThe ability to direct cell behavior has been central to the success of numerous therapeutics to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to understand and modulate the interactions of biomaterials with biological systems in order to achieve effective tissue repair. One key area of research investigates the use of extracellular matrix-derived ligands to target specific integrin interactions and induce cellular responses, such as increased cell migration, proliferation, and differentiation of mesenchymal stem cells. These integrin-targeting proteins and peptides have been implemented in a variety of different polymeric scaffolds and devices to enhance tissue regeneration and integration. This review first presents an overview of integrin-mediaAdvanced healthcare materialse2000795https://www.ebi.ac.uk/biostudies/studies/S-EPMC7960574biostudies-literatureReview of Integrin-Targeting Biomaterials in Tissue Engineering.PMC7960574R21 AR076107R21AR0761071822196Salhadar KJose AKar RShoga EJenkins DChwatko MCosgriff-Hernandez ERobinson AKannapiran ADhavalikar PLan ZfalseReview of Integrin-Targeting Biomaterials in Tissue Engineering.The ability to direct cell behavior has been central to the success of numerous therapeutics to regenerate tissue or facilitate device integration. Biomaterial scientists are challenged to understand and modulate the interactions of biomaterials with biological systems in order to achieve effective tissue repair. One key area of research investigates the use of extracellular matrix-derived ligands to target specific integrin interactions and induce cellular responses, such as increased cell migration, proliferation, and differentiation of mesenchymal stem cells. These integrin-targeting proteins and peptides have been implemented in a variety of different polymeric scaffolds and devices to enhance tissue regeneration and integration. This review first presents an overview of integrin-media2020-01-01T00:00:00Z2020 Sep2025-04-18T12:16:05.369Z2025-04-06T21:49:44.522ZS-EPMC79605743294002010.1002/adhm.202000795