{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26"],"submitter":["Shigeta T"],"pubmed_abstract":["Reducing sugars and reactive aldehydes, such as glyceraldehyde, non-enzymatically react with amino or guanidino groups of proteins to form advanced glycation end-products (AGEs) by the Maillard reaction that involves Schiff base formation followed by Amadori rearrangement. AGEs are found relatively in abundance in the human eye and to accumulate at a higher rate in diseases that impair vision such as cataract, diabetic retinopathy or age-related macular degeneration. We identified two novel AGEs of pyrrolopyridinium lysine dimer derived from glyceraldehyde, PPG1 and PPG2, in the Maillard reaction of <i>N</i> <sup>α</sup>-acetyl-l-lysine with glyceraldehyde under physiological conditions. Having fluorophores similar to that of vesperlysine A, which was isolated from the human lens, PPGs wer"],"journal":["Biochemistry and biophysics reports"],"pagination":["100963"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7960790"],"repository":["biostudies-literature"],"pubmed_title":["Glyceraldehyde-derived advanced glycation end-products having pyrrolopyridinium-based crosslinks."],"pmcid":["PMC7960790"],"pubmed_authors":["Sasamoto K","Shigeta T","Yamamoto T"],"additional_accession":[]},"is_claimable":false,"name":"Glyceraldehyde-derived advanced glycation end-products having pyrrolopyridinium-based crosslinks.","description":"Reducing sugars and reactive aldehydes, such as glyceraldehyde, non-enzymatically react with amino or guanidino groups of proteins to form advanced glycation end-products (AGEs) by the Maillard reaction that involves Schiff base formation followed by Amadori rearrangement. AGEs are found relatively in abundance in the human eye and to accumulate at a higher rate in diseases that impair vision such as cataract, diabetic retinopathy or age-related macular degeneration. We identified two novel AGEs of pyrrolopyridinium lysine dimer derived from glyceraldehyde, PPG1 and PPG2, in the Maillard reaction of <i>N</i> <sup>α</sup>-acetyl-l-lysine with glyceraldehyde under physiological conditions. Having fluorophores similar to that of vesperlysine A, which was isolated from the human lens, PPGs wer","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jul","modification":"2025-04-20T02:28:53.748Z","creation":"2025-04-20T02:28:53.748Z"},"accession":"S-EPMC7960790","cross_references":{"pubmed":["33748437"],"doi":["10.1016/j.bbrep.2021.100963"]}}