{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Johnson EB"],"funding":["Medical Research Council","CHDI Foundation Los Angeles","Wellcome Trust"],"pagination":["103266"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7960938"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65"],"pubmed_abstract":["Background
Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evidence of subtle neurodegeneration. Here, we use novel imaging techniques to determine whether macro- and micro-structural changes can be detected across the whole-brain in the same cohort.Methods
62 premanifest HD (PreHD) and 61 controls from the HD Young Adult Study (HD-YAS) were included. Grey and white matter volume, diffusion weighted imaging (DWI) measures of white matter microstructure, multiparametric maps (MPM) estimating myelin and iron content from magnetization transfer (MT), proton density (PD), longitudinal relaxatio"],"journal":["EBioMedicine"],"pubmed_title":["Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study."],"pmcid":["PMC7960938"],"funding_grant_id":["UKDRI-1008/2","200181/Z/15/Z"],"pubmed_authors":["Fayer K","Rees G","Estevez-Fraga C","Zhang H","Tabrizi SJ","Papoutsi M","Johnson EB","Parker CS","Zeun P","Scahill RI","Gregory S","Osborne-Crowley K","HD-YAS Investigators","Lowe J","Nair A"],"additional_accession":[]},"is_claimable":false,"name":"Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study.","description":"Background
Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was evidence of subtle neurodegeneration. Here, we use novel imaging techniques to determine whether macro- and micro-structural changes can be detected across the whole-brain in the same cohort.Methods
62 premanifest HD (PreHD) and 61 controls from the HD Young Adult Study (HD-YAS) were included. Grey and white matter volume, diffusion weighted imaging (DWI) measures of white matter microstructure, multiparametric maps (MPM) estimating myelin and iron content from magnetization transfer (MT), proton density (PD), longitudinal relaxatio","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-20T02:29:35.901Z","creation":"2025-04-20T02:29:35.901Z"},"accession":"S-EPMC7960938","cross_references":{"pubmed":["33706250"],"doi":["10.1016/j.ebiom.2021.103266"]}}