{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Zhao J"],"pubmed_abstract":["Allograft rejection has been an obstacle for the long-term survival of patients. CD70, a tumor necrosis factor (TNF) family member critically expressed on antigen-presenting cells and strongly but transiently up-regulated during lymphocyte activation, represents an important co-stimulatory molecule that induces effective T cell responses. We used a mouse heterotopic cardiac transplantation model to evaluate the effects of monotherapy with the antibody targeting mouse CD70 (FR70) on transplantation tolerance and its immunoregulatory activity. FR70-treated C3H recipient mice permanently accepted B6 fully mismatched cardiac allografts. Consistent with the graft survival, the infiltration of CD8<sup>+</sup> T cells in the graft was reduced, dendritic cells were differentiated into a tolerogeni"],"journal":["Frontiers in immunology"],"pagination":["555996"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7961176"],"repository":["biostudies-literature"],"pubmed_title":["Monotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells."],"pmcid":["PMC7961176"],"pubmed_authors":["Nonomura N","Zabrocki P","Que W","Fujino M","Ueta H","Du X","Guo WZ","Li XK","de Haard H","Tokuda N","Zhao J","Ichimaru N"],"additional_accession":[]},"is_claimable":false,"name":"Monotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells.","description":"Allograft rejection has been an obstacle for the long-term survival of patients. CD70, a tumor necrosis factor (TNF) family member critically expressed on antigen-presenting cells and strongly but transiently up-regulated during lymphocyte activation, represents an important co-stimulatory molecule that induces effective T cell responses. We used a mouse heterotopic cardiac transplantation model to evaluate the effects of monotherapy with the antibody targeting mouse CD70 (FR70) on transplantation tolerance and its immunoregulatory activity. FR70-treated C3H recipient mice permanently accepted B6 fully mismatched cardiac allografts. Consistent with the graft survival, the infiltration of CD8<sup>+</sup> T cells in the graft was reduced, dendritic cells were differentiated into a tolerogeni","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-21T17:00:57.659Z","creation":"2025-04-21T17:00:57.659Z"},"accession":"S-EPMC7961176","cross_references":{"pubmed":["33737923"],"doi":["10.3389/fimmu.2020.555996"]}}