biostudies-literatureUnknown11Zhao JAllograft rejection has been an obstacle for the long-term survival of patients. CD70, a tumor necrosis factor (TNF) family member critically expressed on antigen-presenting cells and strongly but transiently up-regulated during lymphocyte activation, represents an important co-stimulatory molecule that induces effective T cell responses. We used a mouse heterotopic cardiac transplantation model to evaluate the effects of monotherapy with the antibody targeting mouse CD70 (FR70) on transplantation tolerance and its immunoregulatory activity. FR70-treated C3H recipient mice permanently accepted B6 fully mismatched cardiac allografts. Consistent with the graft survival, the infiltration of CD8⁺ T cells in the graft was reduced, dendritic cells were differentiated into a tolerogeniFrontiers in immunology555996https://www.ebi.ac.uk/biostudies/studies/S-EPMC7961176biostudies-literatureMonotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells.PMC7961176Nonomura NZabrocki PQue WFujino MUeta HDu XGuo WZLi XKde Haard HTokuda NZhao JIchimaru NfalseMonotherapy With Anti-CD70 Antibody Causes Long-Term Mouse Cardiac Allograft Acceptance With Induction of Tolerogenic Dendritic Cells.Allograft rejection has been an obstacle for the long-term survival of patients. CD70, a tumor necrosis factor (TNF) family member critically expressed on antigen-presenting cells and strongly but transiently up-regulated during lymphocyte activation, represents an important co-stimulatory molecule that induces effective T cell responses. We used a mouse heterotopic cardiac transplantation model to evaluate the effects of monotherapy with the antibody targeting mouse CD70 (FR70) on transplantation tolerance and its immunoregulatory activity. FR70-treated C3H recipient mice permanently accepted B6 fully mismatched cardiac allografts. Consistent with the graft survival, the infiltration of CD8⁺ T cells in the graft was reduced, dendritic cells were differentiated into a tolerogeni2020-01-01T00:00:00Z20202025-04-21T17:00:57.659Z2025-04-21T17:00:57.659ZS-EPMC79611763373792310.3389/fimmu.2020.555996