{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lan YT"],"funding":["Ministry of Science and Technology, Taiwan","Taipei Hospital","Taipei Veterans General Hospital"],"pagination":["620146"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7962409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<h4>Background</h4>The prognosis of mucinous adenocarcinoma (MAC) and non-mucinous adenocarcinoma (NMAC) in colorectal cancer (CRC) is controversial, and the molecular differences between them are unclear.<h4>Methods</h4>Between 2000 and 2010, a total of 1,483 CRC patients were included. Among them, 73 patients (4.9%) were diagnosed with MAC. The clinicopathological features and genetic alterations were compared between MAC and NMAC.<h4>Results</h4>After propensity score matching to balance age and sex between MAC and NMAC patients, 292 CRC patients (73 MAC and 219 NMAC) were enrolled in the analysis at a 1:3 ratio. In right-sided colon cancer, patients with MAC were more likely to have Borrmann types 3 and 4 tumors, poor differentiation, and advanced T category and tumor, node, metastasis (TNM) stage, chemotherapy, and a similar 5-year overall survival (OS) rate compared with patients with NMAC. In left-sided colon cancer and rectal cancer, patients with MAC were more likely to have Borrmann types 3 and 4 tumors, poor differentiation, lymphovascular invasion, advanced T and N categories and TNM stages, chemotherapy, and a worse 5-year OS rate than patients with NMAC. Regarding genetic alterations, for NMAC, right-sided colon cancer had more <i>BRAF</i> mutations than left-sided colon cancer and rectal cancer. For MAC, right-sided colon cancer was associated with more microsatellite instability-high tumors and more <i>AKT1</i> mutations than left-sided colon cancer and rectal cancer.<h4>Conclusion</h4>The genetic alterations are distinct between MAC and NMAC in CRC. Tumor location may have an impact on genetic alterations and patient prognosis in MAC and NMAC."],"journal":["Frontiers in oncology"],"pubmed_title":["Clinicopathological and Molecular Features of Colorectal Cancer Patients With Mucinous and Non-Mucinous Adenocarcinoma."],"pmcid":["PMC7962409"],"funding_grant_id":["V105C-043, V106C-027, V107C-004","10601-62-059","105-2314-B-075-010-MY2"],"pubmed_authors":["Chang SC","Huang SC","Lin CC","Lin HH","Chen WS","Lin PC","Lin JK","Yang SH","Lan YT","Lin CH","Liang WY","Jiang JK"],"additional_accession":[]},"is_claimable":false,"name":"Clinicopathological and Molecular Features of Colorectal Cancer Patients With Mucinous and Non-Mucinous Adenocarcinoma.","description":"<h4>Background</h4>The prognosis of mucinous adenocarcinoma (MAC) and non-mucinous adenocarcinoma (NMAC) in colorectal cancer (CRC) is controversial, and the molecular differences between them are unclear.<h4>Methods</h4>Between 2000 and 2010, a total of 1,483 CRC patients were included. Among them, 73 patients (4.9%) were diagnosed with MAC. The clinicopathological features and genetic alterations were compared between MAC and NMAC.<h4>Results</h4>After propensity score matching to balance age and sex between MAC and NMAC patients, 292 CRC patients (73 MAC and 219 NMAC) were enrolled in the analysis at a 1:3 ratio. In right-sided colon cancer, patients with MAC were more likely to have Borrmann types 3 and 4 tumors, poor differentiation, and advanced T category and tumor, node, metastasis (TNM) stage, chemotherapy, and a similar 5-year overall survival (OS) rate compared with patients with NMAC. In left-sided colon cancer and rectal cancer, patients with MAC were more likely to have Borrmann types 3 and 4 tumors, poor differentiation, lymphovascular invasion, advanced T and N categories and TNM stages, chemotherapy, and a worse 5-year OS rate than patients with NMAC. Regarding genetic alterations, for NMAC, right-sided colon cancer had more <i>BRAF</i> mutations than left-sided colon cancer and rectal cancer. For MAC, right-sided colon cancer was associated with more microsatellite instability-high tumors and more <i>AKT1</i> mutations than left-sided colon cancer and rectal cancer.<h4>Conclusion</h4>The genetic alterations are distinct between MAC and NMAC in CRC. Tumor location may have an impact on genetic alterations and patient prognosis in MAC and NMAC.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-21T16:59:38.101Z","creation":"2025-04-21T16:59:38.101Z"},"accession":"S-EPMC7962409","cross_references":{"pubmed":["33738258"],"doi":["10.3389/fonc.2021.620146"]}}