biostudies-literatureTierrafria VHNational Institute of HealthNIHNIGMS NIH HHSFOINS CONACyT Fronteras de la Ciencia856-864https://www.ebi.ac.uk/biostudies/studies/S-EPMC7963087biostudies-literatureUnknown35(5)<h4>Motivation</h4>A major component in increasing our understanding of the biology of an organism is the mapping of its genotypic potential into its phenotypic expression profiles. This mapping is executed by the machinery of gene regulation, which is essentially studied by changes in growth conditions. Although many efforts have been made to systematize the annotation of experimental conditions in microbiology, the available annotations are not based on a consistent and controlled vocabulary, making difficult the identification of biologically meaningful comparisons of knowledge derived from different experiments or laboratories.<h4>Results</h4>We curated terms related to experimental conditions that affect gene expression in Escherichia coli K-12. Since this is the best-studied microorgBioinformatics (Oxford, England)MCO: towards an ontology and unified vocabulary for a framework-based annotation of microbial growth conditions.PMC79630875R01GM110597-03R01 GM110597576333Tierrafria VHMejia-Almonte CCollado-Vides JCamacho-Zaragoza JMSalgado HIshida CAlquicira KGama-Castro SfalseMCO: towards an ontology and unified vocabulary for a framework-based annotation of microbial growth conditions.<h4>Motivation</h4>A major component in increasing our understanding of the biology of an organism is the mapping of its genotypic potential into its phenotypic expression profiles. This mapping is executed by the machinery of gene regulation, which is essentially studied by changes in growth conditions. Although many efforts have been made to systematize the annotation of experimental conditions in microbiology, the available annotations are not based on a consistent and controlled vocabulary, making difficult the identification of biologically meaningful comparisons of knowledge derived from different experiments or laboratories.<h4>Results</h4>We curated terms related to experimental conditions that affect gene expression in Escherichia coli K-12. Since this is the best-studied microorg2019-01-01T00:00:00Z2019 Mar2026-07-16T18:16:34.402Z2025-02-18T23:48:48.121ZS-EPMC79630873013721010.1093/bioinformatics/bty689