{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Popov A"],"funding":["Russian Science Foundation"],"pagination":["e13334"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7963330"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive astrogliosis and astrocytic hypertrophy requires scrutiny and detailed analysis. Using two-photon microscopy in conjunction with 3D reconstruction, Sholl and volume fraction analysis, we demonstrate a significant reduction in the number and the length of astrocytic processes, in astrocytic territorial domains and in astrocyte-to-astrocyte coupling in the aged brain. Probing physiology of astrocytes with patch clamp, and Ca<sup>2+</sup> imaging revealed deficits in K<sup>+</sup> and glutamate clearance and spatiotemporal reorganisation of Ca<sup>2+</sup> events in old astro"],"journal":["Aging cell"],"pubmed_title":["Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity."],"pmcid":["PMC7963330"],"funding_grant_id":["20‐14‐00241"],"pubmed_authors":["Verkhratsky A","Popov A","Brazhe A","Denisov P","Semyanov A","Li L","Lazareva N","Sutyagina O"],"additional_accession":[]},"is_claimable":false,"name":"Astrocyte dystrophy in ageing brain parallels impaired synaptic plasticity.","description":"Little is known about age-dependent changes in structure and function of astrocytes and of the impact of these on the cognitive decline in the senescent brain. The prevalent view on the age-dependent increase in reactive astrogliosis and astrocytic hypertrophy requires scrutiny and detailed analysis. Using two-photon microscopy in conjunction with 3D reconstruction, Sholl and volume fraction analysis, we demonstrate a significant reduction in the number and the length of astrocytic processes, in astrocytic territorial domains and in astrocyte-to-astrocyte coupling in the aged brain. Probing physiology of astrocytes with patch clamp, and Ca<sup>2+</sup> imaging revealed deficits in K<sup>+</sup> and glutamate clearance and spatiotemporal reorganisation of Ca<sup>2+</sup> events in old astro","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-18T13:28:36.09Z","creation":"2025-04-06T23:15:00.255Z"},"accession":"S-EPMC7963330","cross_references":{"pubmed":["33675569"],"doi":["10.1111/acel.13334"]}}