{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saleh M"],"funding":["NCATS NIH HHS","Harvard Clinical and Translational Science Center","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","Specialized Centers of Clinically Oriented Research (SCCOR)"],"pagination":["34-41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7963403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["277"],"pubmed_abstract":["<h4>Background and aims</h4>Hypertension is associated with increased clinical and subclinical coronary artery disease (CAD); however, the relationship between blood pressure and coronary plaque volume is unclear. We examined the effect of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on coronary artery plaque volume.<h4>Methods</h4>285 subjects with stable CAD on statin therapy underwent coronary computed tomographic angiography to measure volume of fatty, fibrous, noncalcified, calcified and total coronary plaque.<h4>Results</h4>Mean (SD) age was 63.1 (7.7); mean (SD) LDL-C, 78.7 mg/dL (28.5). Compared to the highest DBP tertile (>76 mmHg), those in the lowest DBP tertile (≤68 mmHg) had lower volumes of fatty: 10.0 vs. 7.7 mm<sup>3</sup>/mm, (p trend = 0.042), fibrous: 19.6 vs. 13.8 mm<sup>3</sup>/mm (p trend = 0.011), non-calcified: 29.7 vs. 22.5 mm<sup>3</sup>/mm (p trend = 0.017) and total plaque: 37.8 vs. 25.1 mm<sup>3</sup>/mm (p trend = 0.010) whereas there was no relationship with SBP tertiles. Similarly, when examined as a continuous variable, higher DBP was a significant independent predictor of higher plaque volume after multivariate adjustment: for every 1 mmHg increase in DBP, fibrous plaque increased 0.128 mm<sup>3</sup>/mm (p = 0.022), noncalcified plaque increased 0.176 mm<sup>3</sup>/mm (p = 0.045), calcified plaque increased 0.096 mm<sup>3</sup>/mm (p = 0.001) and total plaque increased 0.249 mm<sup>3</sup>/mm (p = 0.019) whereas SBP ranging from 95 to 154 mmHg did not predict plaque volume.<h4>Conclusions</h4>Level of DBP predicts coronary plaque with a DBP tertile ≤68 mmHg associated with the least amount of coronary plaque in subjects with LDL-C < 80 mg/dL."],"journal":["Atherosclerosis"],"pubmed_title":["Diastolic blood pressure predicts coronary plaque volume in patients with coronary artery disease."],"pmcid":["PMC7963403"],"funding_grant_id":["UL1 TR001102","P50 HL083813","NIH UL1 TR001102"],"pubmed_authors":["Saleh M","Haj-Ibrahim H","Alfaddagh A","Welty FK","Ashfaque H","Elajami TK"],"additional_accession":[]},"is_claimable":false,"name":"Diastolic blood pressure predicts coronary plaque volume in patients with coronary artery disease.","description":"<h4>Background and aims</h4>Hypertension is associated with increased clinical and subclinical coronary artery disease (CAD); however, the relationship between blood pressure and coronary plaque volume is unclear. We examined the effect of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on coronary artery plaque volume.<h4>Methods</h4>285 subjects with stable CAD on statin therapy underwent coronary computed tomographic angiography to measure volume of fatty, fibrous, noncalcified, calcified and total coronary plaque.<h4>Results</h4>Mean (SD) age was 63.1 (7.7); mean (SD) LDL-C, 78.7 mg/dL (28.5). Compared to the highest DBP tertile (>76 mmHg), those in the lowest DBP tertile (≤68 mmHg) had lower volumes of fatty: 10.0 vs. 7.7 mm<sup>3</sup>/mm, (p trend = 0.042), fibrous: 19.6 vs. 13.8 mm<sup>3</sup>/mm (p trend = 0.011), non-calcified: 29.7 vs. 22.5 mm<sup>3</sup>/mm (p trend = 0.017) and total plaque: 37.8 vs. 25.1 mm<sup>3</sup>/mm (p trend = 0.010) whereas there was no relationship with SBP tertiles. Similarly, when examined as a continuous variable, higher DBP was a significant independent predictor of higher plaque volume after multivariate adjustment: for every 1 mmHg increase in DBP, fibrous plaque increased 0.128 mm<sup>3</sup>/mm (p = 0.022), noncalcified plaque increased 0.176 mm<sup>3</sup>/mm (p = 0.045), calcified plaque increased 0.096 mm<sup>3</sup>/mm (p = 0.001) and total plaque increased 0.249 mm<sup>3</sup>/mm (p = 0.019) whereas SBP ranging from 95 to 154 mmHg did not predict plaque volume.<h4>Conclusions</h4>Level of DBP predicts coronary plaque with a DBP tertile ≤68 mmHg associated with the least amount of coronary plaque in subjects with LDL-C < 80 mg/dL.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Oct","modification":"2025-04-18T18:57:23.388Z","creation":"2025-04-07T06:41:15.78Z"},"accession":"S-EPMC7963403","cross_references":{"pubmed":["30170222"],"doi":["10.1016/j.atherosclerosis.2018.07.031"]}}