biostudies-literatureUnknown38(9)van den Bouwhuijsen QJA<h4>Background and purpose</h4>Vulnerable carotid plaque components are reported to increase the risk of cerebrovascular events. Yet, the relation between plaque composition and subclinical ischemic brain disease is not known. We studied, in the general population, the association between carotid atherosclerotic plaque characteristics and ischemic brain disease on MR imaging.<h4>Materials and methods</h4>From the population-based Rotterdam Study, 951 participants underwent both carotid MR imaging and brain MR imaging. The presence of intraplaque hemorrhage, lipid core, and calcification and measures of plaque size was assessed in both carotid arteries. The presence of plaque characteristics in relation to lacunar and cortical infarcts and white matter lesion volume was investigated and adjAJNR. American journal of neuroradiology1776-1782https://www.ebi.ac.uk/biostudies/studies/S-EPMC7963699biostudies-literatureCarotid Plaque Morphology and Ischemic Vascular Brain Disease on MRI.PMC7963699Vernooij MWNiessen WJFranco OHvan den Bouwhuijsen QJAKrestin GPVerhaaren BFJIkram MAvan der Lugt AVrooman HAfalseCarotid Plaque Morphology and Ischemic Vascular Brain Disease on MRI.<h4>Background and purpose</h4>Vulnerable carotid plaque components are reported to increase the risk of cerebrovascular events. Yet, the relation between plaque composition and subclinical ischemic brain disease is not known. We studied, in the general population, the association between carotid atherosclerotic plaque characteristics and ischemic brain disease on MR imaging.<h4>Materials and methods</h4>From the population-based Rotterdam Study, 951 participants underwent both carotid MR imaging and brain MR imaging. The presence of intraplaque hemorrhage, lipid core, and calcification and measures of plaque size was assessed in both carotid arteries. The presence of plaque characteristics in relation to lacunar and cortical infarcts and white matter lesion volume was investigated and adj2017-01-01T00:00:00Z2017 Sep2025-04-05T15:24:50.805Z2025-04-05T15:24:50.805ZS-EPMC79636992870582410.3174/ajnr.A528810.3174/ajnr.a5288