{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["35(9)"],"submitter":["Manara R"],"pubmed_abstract":["<h4>Background and purpose</h4>Kallmann syndrome is a rare inherited disorder due to defective intrauterine migration of olfactory axons and gonadotropin-releasing hormone neurons, leading to rhinencephalon hypoplasia and hypogonadotropic hypogonadism. Concomitant brain developmental abnormalities have been described. Our aim was to investigate Kallmann syndrome-related brain changes with conventional and novel quantitative MR imaging analyses.<h4>Materials and methods</h4>Forty-five male patients with Kallmann syndrome (mean age, 30.7 years; range, 9-55 years) and 23 age-matched male controls underwent brain MR imaging. The MR imaging study protocol included 3D-T1, FLAIR, and diffusion tensor imaging (32 noncollinear gradient-encoding directions; b-value=800 s/mm2). Voxel-based morphometr"],"journal":["AJNR. American journal of neuroradiology"],"pagination":["1700-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7966280"],"repository":["biostudies-literature"],"pubmed_title":["Brain changes in Kallmann syndrome."],"pmcid":["PMC7966280"],"pubmed_authors":["Elefante A","Kallmann Syndrome Neuroradiological Study Group","Ottaviano G","Rizzati S","Rossato M","Di Salle F","Salvalaggio A","Bonanni G","Cantone E","Briani C","Coppola G","Manara R","D'Errico A","Napoli E","Favaro A","Sinisi AA","De Carlo E","Palumbo V","Greggio NA","D'Agosto G","Citton V","Brunetti A"],"additional_accession":[]},"is_claimable":false,"name":"Brain changes in Kallmann syndrome.","description":"<h4>Background and purpose</h4>Kallmann syndrome is a rare inherited disorder due to defective intrauterine migration of olfactory axons and gonadotropin-releasing hormone neurons, leading to rhinencephalon hypoplasia and hypogonadotropic hypogonadism. Concomitant brain developmental abnormalities have been described. Our aim was to investigate Kallmann syndrome-related brain changes with conventional and novel quantitative MR imaging analyses.<h4>Materials and methods</h4>Forty-five male patients with Kallmann syndrome (mean age, 30.7 years; range, 9-55 years) and 23 age-matched male controls underwent brain MR imaging. The MR imaging study protocol included 3D-T1, FLAIR, and diffusion tensor imaging (32 noncollinear gradient-encoding directions; b-value=800 s/mm2). Voxel-based morphometr","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-18T17:40:56.75Z","creation":"2025-04-07T05:17:46.068Z"},"accession":"S-EPMC7966280","cross_references":{"pubmed":["24788131"],"doi":["10.3174/ajnr.a3946","10.3174/ajnr.A3946"]}}