biostudies-literatureUnknown35(9)Manara R<h4>Background and purpose</h4>Kallmann syndrome is a rare inherited disorder due to defective intrauterine migration of olfactory axons and gonadotropin-releasing hormone neurons, leading to rhinencephalon hypoplasia and hypogonadotropic hypogonadism. Concomitant brain developmental abnormalities have been described. Our aim was to investigate Kallmann syndrome-related brain changes with conventional and novel quantitative MR imaging analyses.<h4>Materials and methods</h4>Forty-five male patients with Kallmann syndrome (mean age, 30.7 years; range, 9-55 years) and 23 age-matched male controls underwent brain MR imaging. The MR imaging study protocol included 3D-T1, FLAIR, and diffusion tensor imaging (32 noncollinear gradient-encoding directions; b-value=800 s/mm2). Voxel-based morphometrAJNR. American journal of neuroradiology1700-6https://www.ebi.ac.uk/biostudies/studies/S-EPMC7966280biostudies-literatureBrain changes in Kallmann syndrome.PMC7966280Elefante AKallmann Syndrome Neuroradiological Study GroupOttaviano GRizzati SRossato MDi Salle FSalvalaggio ABonanni GCantone EBriani CCoppola GManara RD'Errico ANapoli EFavaro ASinisi AADe Carlo EPalumbo VGreggio NAD'Agosto GCitton VBrunetti AfalseBrain changes in Kallmann syndrome.<h4>Background and purpose</h4>Kallmann syndrome is a rare inherited disorder due to defective intrauterine migration of olfactory axons and gonadotropin-releasing hormone neurons, leading to rhinencephalon hypoplasia and hypogonadotropic hypogonadism. Concomitant brain developmental abnormalities have been described. Our aim was to investigate Kallmann syndrome-related brain changes with conventional and novel quantitative MR imaging analyses.<h4>Materials and methods</h4>Forty-five male patients with Kallmann syndrome (mean age, 30.7 years; range, 9-55 years) and 23 age-matched male controls underwent brain MR imaging. The MR imaging study protocol included 3D-T1, FLAIR, and diffusion tensor imaging (32 noncollinear gradient-encoding directions; b-value=800 s/mm2). Voxel-based morphometr2014-01-01T00:00:00Z2014 Sep2025-04-18T17:40:56.75Z2025-04-07T05:17:46.068ZS-EPMC79662802478813110.3174/ajnr.a394610.3174/ajnr.A3946