{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muzerelle A"],"funding":["Saint Petersburg State University","Campus France","Agence Nationale de la Recherche","DAAD Program","ERA-NET NEURON","Wolkswagen Foundation","LabEx BioPsy"],"pagination":["6004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7966367"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nur"],"journal":["Scientific reports"],"pubmed_title":["Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival."],"pmcid":["PMC7966367"],"funding_grant_id":["RESPOND","16-0162","ANR-11-0004-02","57211823","35470WD","RESPOND/ANR-15-0179","51143531"],"pubmed_authors":["Ruet PL","Muzerelle A","Alenina N","Hainer C","Scotto-Lomassese S","Lesch KP","Soiza-Reilly M","Bader M","Gaspar P"],"additional_accession":[]},"is_claimable":false,"name":"Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival.","description":"Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nur","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Mar","modification":"2025-04-26T00:45:50.573Z","creation":"2025-04-06T09:48:02.32Z"},"accession":"S-EPMC7966367","cross_references":{"pubmed":["33727585"],"doi":["10.1038/s41598-021-84368-6"]}}