{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Cunningham CC"],"pubmed_abstract":["Background
MicroRNAs (miRNAs) are small non-coding RNAs which have been implicated as potential biomarkers or therapeutic targets in autoimmune diseases. This study examines circulatory miRNAs in RA patients and further investigates if a serum miRNA signature precedes clinical manifestations of disease in arthralgia or \"at-risk individuals\".Methods
Serum was collected from HC subjects (N = 20), RA patients (N = 50), and arthralgia subjects (N = 10), in addition to a subgroup of the RA patients post-methotrexate (MTX) (N = 18). The FirePlex miRNA Immunology-V2 panel was selected for multiplex analysis of 68 miRNAs in each sample. DNA intelligent analysis (DIANA)-mirPath and Ingenuity Pathway Analysis (IPA) software were used to predict pathways targeted by the dysregulated m"],"journal":["Frontiers in immunology"],"pagination":["633201"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7966707"],"repository":["biostudies-literature"],"pubmed_title":["Serum miRNA Signature in Rheumatoid Arthritis and \"At-Risk Individuals\"."],"pmcid":["PMC7966707"],"pubmed_authors":["Wade S","Floudas A","Cregan S","Cunningham CC","McGarry T","Veale DJ","Orr C","Fearon U"],"additional_accession":[]},"is_claimable":false,"name":"Serum miRNA Signature in Rheumatoid Arthritis and \"At-Risk Individuals\".","description":"Background
MicroRNAs (miRNAs) are small non-coding RNAs which have been implicated as potential biomarkers or therapeutic targets in autoimmune diseases. This study examines circulatory miRNAs in RA patients and further investigates if a serum miRNA signature precedes clinical manifestations of disease in arthralgia or \"at-risk individuals\".Methods
Serum was collected from HC subjects (N = 20), RA patients (N = 50), and arthralgia subjects (N = 10), in addition to a subgroup of the RA patients post-methotrexate (MTX) (N = 18). The FirePlex miRNA Immunology-V2 panel was selected for multiplex analysis of 68 miRNAs in each sample. DNA intelligent analysis (DIANA)-mirPath and Ingenuity Pathway Analysis (IPA) software were used to predict pathways targeted by the dysregulated m","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-18T16:39:07.56Z","creation":"2025-04-07T03:58:40.689Z"},"accession":"S-EPMC7966707","cross_references":{"pubmed":["33746971"],"doi":["10.3389/fimmu.2021.633201"]}}