biostudies-literatureYang MXStanford Graduate FellowshipStanford SystemX AllianceNational Science Foundation, United StatesNational Institutes of HealthMultidisciplinary University Research InitiativeChan Zuckerberg InitiativeNIH HHS5967https://www.ebi.ac.uk/biostudies/studies/S-EPMC7966781biostudies-literatureUnknown11(1)The rapid growth and development of technology has had significant implications for healthcare, personalized medicine, and our understanding of biology. In this work, we leverage the miniaturization of electronics to realize the first demonstration of wireless detection and communication of an electronic device inside a cell. This is a significant forward step towards a vision of non-invasive, intracellular wireless platforms for single-cell analyses. We demonstrate that a 25 [Formula: see text]m wireless radio frequency identification (RFID) device can not only be taken up by a mammalian cell but can also be detected and specifically identified externally while located intracellularly. The S-parameters and power delivery efficiency of the electronic communication system is quantified befoScientific reportsIntracellular detection and communication of a wireless chip in cell.PMC7966781U54CA199075Wong HPAkin DYang MXHu XPoon AfalseIntracellular detection and communication of a wireless chip in cell.The rapid growth and development of technology has had significant implications for healthcare, personalized medicine, and our understanding of biology. In this work, we leverage the miniaturization of electronics to realize the first demonstration of wireless detection and communication of an electronic device inside a cell. This is a significant forward step towards a vision of non-invasive, intracellular wireless platforms for single-cell analyses. We demonstrate that a 25 [Formula: see text]m wireless radio frequency identification (RFID) device can not only be taken up by a mammalian cell but can also be detected and specifically identified externally while located intracellularly. The S-parameters and power delivery efficiency of the electronic communication system is quantified befo2021-01-01T00:00:00Z2021 Mar2025-04-05T22:30:35.618Z2025-04-05T22:30:35.618ZS-EPMC79667813372759810.1038/s41598-021-85268-5