{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fasolo F"],"funding":["British Heart Foundation","National Centre for the Replacement, Refinement and Reduction of Animals in Research","Ragnar Söderberg Foundation Fellowship","German Research Council","NHLBI NIH HHS","Swedish Research Council","NIH","Cardiovascular Research","Research in Lars Maegdefessel’s labs","European Research Council","British Heart Foundation Senior Basic Science Research","DZHK","Swedish Heart-Lung Foundation"],"pagination":["1732-1756"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7967706"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(12)"],"pubmed_abstract":["Atherosclerosis underlies the predominant number of cardiovascular diseases and remains a leading cause of morbidity and mortality worldwide. The development, progression and formation of clinically relevant atherosclerotic plaques involves the interaction of distinct and over-lapping mechanisms which dictate the roles and actions of multiple resident and recruited cell types including endothelial cells, vascular smooth muscle cells, and monocyte/macrophages. The discovery of non-coding RNAs (ncRNAs) including microRNAs, long non-coding RNAs, and circular RNAs, and their identification as key mechanistic regulators of mRNA and protein expression has piqued interest in their potential contribution to atherosclerosis. Accruing evidence has revealed ncRNAs regulate pivotal cellular and molecu"],"journal":["Cardiovascular research"],"pubmed_title":["Non-coding RNAs in cardiovascular cell biology and atherosclerosis."],"pmcid":["PMC7967706"],"funding_grant_id":["R01 HL135093","NC/N003268/1","CRC1123","PG/15/30/31390","PG/18/84/34124","HLF, 20180680","2015-03140","FS/18/1/33234","R01 HL130423"],"pubmed_authors":["Johnson JL","Fasolo F","Maegdefessel L","Di Gregoli K"],"additional_accession":[]},"is_claimable":false,"name":"Non-coding RNAs in cardiovascular cell biology and atherosclerosis.","description":"Atherosclerosis underlies the predominant number of cardiovascular diseases and remains a leading cause of morbidity and mortality worldwide. The development, progression and formation of clinically relevant atherosclerotic plaques involves the interaction of distinct and over-lapping mechanisms which dictate the roles and actions of multiple resident and recruited cell types including endothelial cells, vascular smooth muscle cells, and monocyte/macrophages. The discovery of non-coding RNAs (ncRNAs) including microRNAs, long non-coding RNAs, and circular RNAs, and their identification as key mechanistic regulators of mRNA and protein expression has piqued interest in their potential contribution to atherosclerosis. Accruing evidence has revealed ncRNAs regulate pivotal cellular and molecu","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-21T18:24:40.31Z","creation":"2025-04-05T17:15:03.542Z"},"accession":"S-EPMC7967706","cross_references":{"pubmed":["31389987"],"doi":["10.1093/cvr/cvz203"]}}