biostudies-literatureFan KNational Key Research and Development projects intergovernmental cooperation in science and technology of ChinaNational Natural Science Foundation of Chinathe Public Welfare Technology Research Program of Zhejiang ProvinceNational Natural Science Foundation of Zhejiang Provincethe Cooperation Project of Lishui City and Zhejiang University76https://www.ebi.ac.uk/biostudies/studies/S-EPMC7968241biostudies-literatureUnknown19(1)<h4>Background</h4>Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Magnetic resonance imaging (MRI) is one of the most effective imaging methods for the early diagnosis of HCC. However, the current MR contrast agents are still facing challenges in the early diagnosis of HCC due to their relatively low sensitivity and biosafety. Thus, the development of effective MR agents is highly needed for the early diagnosis of HCC.<h4>Results</h4>Herein, we fabricated an HCC-targeted nanocomplexes containing SPIO-loaded mesoporous polydopamine (MPDA@SPIO), sialic acid (SA)-modified polyethyleneimine (SA-PEI), and alpha-fetoprotein regulated ferritin gene (AFP-Fth) which was developed for the early diagnosis of HCC. It was found that the prepared nanocomplexes (MPDA@SPIOJournal of nanobiotechnologySialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC.PMC7968241LGF19H1800092018zdhz06LY20H18001681901852LGD19H160002819018482018YFE0126900Xu MShu GQiao EChen MLu CZhang NDu YJi JChen CWu FZhao ZSong JLv XLYang WFan KXu XSun JfalseSialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC.<h4>Background</h4>Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Magnetic resonance imaging (MRI) is one of the most effective imaging methods for the early diagnosis of HCC. However, the current MR contrast agents are still facing challenges in the early diagnosis of HCC due to their relatively low sensitivity and biosafety. Thus, the development of effective MR agents is highly needed for the early diagnosis of HCC.<h4>Results</h4>Herein, we fabricated an HCC-targeted nanocomplexes containing SPIO-loaded mesoporous polydopamine (MPDA@SPIO), sialic acid (SA)-modified polyethyleneimine (SA-PEI), and alpha-fetoprotein regulated ferritin gene (AFP-Fth) which was developed for the early diagnosis of HCC. It was found that the prepared nanocomplexes (MPDA@SPIO2021-01-01T00:00:00Z2021 Mar2025-04-04T12:53:40.796Z2024-12-04T07:20:14.827ZS-EPMC79682413373114010.1186/s12951-021-00821-8