biostudies-literatureUnknown21(1)Uchiyama K<h4>Background</h4>The role of IL-12/23 in the pathogenesis of ulcerative colitis (UC) is unclear. We analyzed mucosal IL-12/23 expression and its relationship with endoscopic severity, histological activity, and UC relapse.<h4>Methods</h4>Rectal biopsies were collected from 70 UC patients with clinical remission. IL-12, IL-23, IFN-γ, IL-17A, and IL-17F mRNA expression was measured by real-time PCR. Endoscopic severity and histological activity were evaluated using the Mayo endoscopic subscore (MES) and the Geboes score, respectively.<h4>Results</h4>The longest follow-up period was 51 months. Thirty-four patients relapsed during the study period. Samples from these subsequently relapsed patients formed the "relapse" group, while those from patients that did not relapse formed the "remissioBMC gastroenterology122https://www.ebi.ac.uk/biostudies/studies/S-EPMC7968323biostudies-literatureIncreased mucosal IL-12 expression is associated with relapse of ulcerative colitis.PMC7968323Naito YIshikawa TTakagi TToyokawa YKamada KKashiwagi SUchiyama KHotta YMizushima KKajiwara-Kubota MKonishi HItoh YKishimoto MTanaka MfalseIncreased mucosal IL-12 expression is associated with relapse of ulcerative colitis.<h4>Background</h4>The role of IL-12/23 in the pathogenesis of ulcerative colitis (UC) is unclear. We analyzed mucosal IL-12/23 expression and its relationship with endoscopic severity, histological activity, and UC relapse.<h4>Methods</h4>Rectal biopsies were collected from 70 UC patients with clinical remission. IL-12, IL-23, IFN-γ, IL-17A, and IL-17F mRNA expression was measured by real-time PCR. Endoscopic severity and histological activity were evaluated using the Mayo endoscopic subscore (MES) and the Geboes score, respectively.<h4>Results</h4>The longest follow-up period was 51 months. Thirty-four patients relapsed during the study period. Samples from these subsequently relapsed patients formed the "relapse" group, while those from patients that did not relapse formed the "remissio2021-01-01T00:00:00Z2021 Mar2025-04-22T08:18:20.146Z2025-04-05T22:29:12.03ZS-EPMC79683233373099810.1186/s12876-021-01709-5